ENSDARG00000070425


Danio rerio

Features
Gene ID: ENSDARG00000070425
  
Biological name :dll4
  
Synonyms : delta-like 4 (Drosophila) / dll4
  
Possible biological names infered from orthology : delta like canonical Notch ligand 4 / Delta-like protein 4 / Q9JI71 / Q9NR61
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 28245164
Gene end: 28257992
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000094097
Ensembl peptide - ENSDARP00000147085
NCBI entrez gene - 563920     See in Manteia.
RefSeq - NM_001079835
RefSeq Peptide - NP_001073304
swissprot - Q5SPB5
ZFIN ID - ZDB-GENE-041014-73
Ensembl - ENSDARG00000070425
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLL4ENSGALG00000008514Gallus gallus
 DLL4ENSG00000128917Homo sapiens
 Dll4ENSMUSG00000027314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000002021949
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG0000001079147
dlc / deltaCENSDARG0000000233645
dlb / deltaB / O57409ENSDARG0000000423241
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138931
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316830
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028930
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424629
notch3 / Q9UM47*ENSDARG0000005213927
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209426
notch2 / Q04721*ENSDARG0000004313026
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355425
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443319
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043296


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IMP
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0035907 dorsal aorta development IGI
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IMP
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0060840 artery development IMP
 biological_processGO:0060841 venous blood vessel development IMP
 biological_processGO:0060854 branching involved in lymph vessel morphogenesis IMP
 biological_processGO:0060855 venous endothelial cell migration involved in lymph vessel development IMP
 biological_processGO:1903670 regulation of sprouting angiogenesis IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
dorsal aorta has extra parts of type endothelial tip cell , abnormal
dorsal aorta morphology , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000112 gut gut blood vasculature increased amount , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein lacks parts or has fewer parts of type endothelial tip cell , abnormal
posterior cardinal vein morphology , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery decreased amount , abnormal
intersegmental artery structure , abnormal
intersegmental artery blood vessel endothelial cell increased amount , abnormal
intersegmental artery absent , abnormal
intersegmental artery increased branchiness , abnormal
intersegmental artery branchiness , ameliorated
Show

 ZFA:0001161 pectoral fin pectoral fin blood vasculature increased amount , abnormal
Show

 ZFA:0001184 pelvic fin pelvic fin deformed , abnormal
Show

 ZFA:0001267 cranial vasculature cranial vasculature branchiness , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel decreased size , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel increased branchiness , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel nucleus decreased amount , abnormal
intersegmental vessel morphology , abnormal
intersegmental vessel has extra parts of type endothelial cell , abnormal
intersegmental vessel nucleus increased amount , abnormal
intersegmental vessel cell increased amount , abnormal
intersegmental vessel malformed , abnormal
intersegmental vessel has extra parts of type intersegmental vein , abnormal
intersegmental vessel endothelial cell amount , ameliorated
intersegmental vessel decreased length , ameliorated
Show

 ZFA:0001554 lepidotrichium lepidotrichium shortened , abnormal
Show

 ZFA:0005000 basal communicating artery basal communicating artery increased size , abnormal
Show

 ZFA:0005020 central artery central artery increased amount , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature branchiness , abnormal
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 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct hypotrophic , abnormal
thoracic duct wholeness , abnormal
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 ZFA:0005177 VeLD VeLD increased amount , abnormal
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 ZFA:0005233 CiD CiD increased amount , abnormal
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 ZFA:0005297 cranial blood vessel cranial blood vessel artery morphogenesis process quality , abnormal
Show

 ZFA:0005603 lymphangiogenic sprout lymphangiogenic sprout decreased amount , abnormal
Show

 ZFA:0005605 lymphangioblast cord lymphangioblast cord lymphangioblast decreased amount , abnormal
lymphangioblast cord absent , abnormal
Show

 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell increased amount , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell cytoplasm spatial pattern , abnormal
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 ZFA:0009303 endothelial tip cell endothelial tip cell spatial pattern , abnormal
Show

 ZFA:0009393 lymphangioblast lymphangioblast decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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