ENSMUSG00000014773


Mus musculus

Features
Gene ID: ENSMUSG00000014773
  
Biological name :Dll1
  
Synonyms : Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form / Dll1 / Q61483
  
Possible biological names infered from orthology : delta like canonical Notch ligand 1 / O00548
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A2
Gene start: 15367354
Gene end: 15376872
  
Corresponding Affymetrix probe sets: 10448034 (MoGene1.0st)   1419204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014917
NCBI entrez gene - 13388     See in Manteia.
MGI - MGI:104659
RefSeq - NM_007865
RefSeq - XM_011246267
RefSeq Peptide - NP_031891
swissprot - Q61483
Ensembl - ENSMUSG00000014773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlaENSDARG00000010791Danio rerio
 dldENSDARG00000020219Danio rerio
 DLL1ENSGALG00000011182Gallus gallus
 DLL1ENSG00000198719Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dll4 / Q9JI71 / Delta-like protein 4 / Q9NR61* / delta like canonical Notch ligand 4*ENSMUSG0000002731447
Jag2 / Q9QYE5 / Protein jagged-2 / Q9Y219* / jagged 2*ENSMUSG0000000279933
Jag1 / Q9QXX0 / Protein jagged-1 / P78504* / jagged 1*ENSMUSG0000002727631
Notch2 / Q04721*ENSMUSG0000002787828
Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*ENSMUSG0000002692328
Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*ENSMUSG0000003814627
Notch4 / Q99466*ENSMUSG0000001546825
Sned1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSMUSG0000004779322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development NAS
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001757 somite specification IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002315 marginal zone B cell differentiation IMP
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway ISO
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007386 compartment pattern specification IMP
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009887 animal organ morphogenesis NAS
 biological_processGO:0009912 auditory receptor cell fate commitment NAS
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0014807 regulation of somitogenesis IMP
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0021688 cerebellar molecular layer formation IMP
 biological_processGO:0021693 cerebellar Purkinje cell layer structural organization IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IMP
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IMP
 biological_processGO:0035265 organ growth IMP
 biological_processGO:0040008 regulation of growth IMP
 biological_processGO:0042472 inner ear morphogenesis NAS
 biological_processGO:0042475 odontogenesis of dentin-containing tooth NAS
 biological_processGO:0042491 inner ear auditory receptor cell differentiation NAS
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045605 negative regulation of epidermal cell differentiation IMP
 biological_processGO:0045608 negative regulation of inner ear auditory receptor cell differentiation IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0045807 positive regulation of endocytosis IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046331 lateral inhibition IMP
 biological_processGO:0048630 skeletal muscle tissue growth IMP
 biological_processGO:0048631 regulation of skeletal muscle tissue growth IMP
 biological_processGO:0048633 positive regulation of skeletal muscle tissue growth IMP
 biological_processGO:0048665 neuron fate specification IDA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0051302 regulation of cell division IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060853 Notch signaling pathway involved in arterial endothelial cell fate commitment IMP
 biological_processGO:0061314 Notch signaling involved in heart development IC
 biological_processGO:0070986 left/right axis specification IMP
 biological_processGO:0072006 nephron development IMP
 biological_processGO:0072014 proximal tubule development IEP
 biological_processGO:0072070 loop of Henle development IEP
 biological_processGO:0072583 clathrin-dependent endocytosis ISS
 biological_processGO:0097102 endothelial tip cell fate specification IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:0098773 skin epidermis development IMP
 biological_processGO:1900746 regulation of vascular endothelial growth factor signaling pathway IMP
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IMP
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030957 Tat protein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Phka1I/FnLn/Y
Genetic Background: I/FnLn

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Phka1I/FnLn/Y
Genetic Background: I/FnLn

Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8Lop10/Gja8tm1Scr
Genetic Background: involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dll1m594592Hubr/Dll1m594592Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8Lop10/Gja8tm1Scr
Genetic Background: involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Phka1I/FnLn/Y
Genetic Background: I/FnLn

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8Lop10/Gja8tm1Scr
Genetic Background: involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dll1m594592Hubr/Dll1m594592Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dll1tm1.1Hri/Dll1tm1.1Hri,Foxa2tm3.1(icre)Heli/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll1m594592Hubr/Dll1m594592Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004132 absent embryonic cilia "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004190 abnormal direction of embryo turning "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Dll1m594592Hubr/Dll1m594592Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004330 abnormal saccular macula morphology "any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dll1tm2Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1+,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dll1tm2Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1+,Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1tm2Gos,Jag2tm1Grid/Jag2tm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0006135 arterial stenosis "abnormal narrowing of the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja8Lop10/Gja8tm1Scr
Genetic Background: involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Snj/Mdm2tm1Snj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008137 absent podocytes "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Jag1tm1Frad/Jag1tm1Frad,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

 MP:0008822 decreased blood uric acid level "reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1m1Mhda/Dll1+
Genetic Background: C3HeB/FeJ-Dll1m1Mhda

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0010119 abnormal bone mineral density "anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8Lop10/Gja8tm1Scr
Genetic Background: involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J

Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010515 abnormal Q wave "any anomaly in the downward deflection in the ECG occuring after the PR interval that represents depolarization of the interventricular septum" [PMID:16939833]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Dll1tm1Gos/Dll1tm2Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Alx3tm1Hubr/Alx3tm1Hubr,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Phka1I/FnLn/Y
Genetic Background: I/FnLn

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Jag1tm1Frad/Jag1tm1Frad,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

 MP:0012024 abnormal nephron morphogenesis "any anomaly in the process in which the nephron is generated and organized; the nephron is the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle" [MGI:csmith]
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Allelic Composition: Notch1tm6.1Rko/Notch1tm6.1Rko,Notch2tm3Grid/Notch2tm3Grid,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Jag1tm1Frad/Jag1+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012728 abnormal somite border morphology "any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [MGI:anna]
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Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
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Allelic Composition: Dll1tm1Gos/Dll1+
Genetic Background: C3Fe.129-Dll1tm1Gos

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / reaction / complex
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / reaction






 

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