ENSG00000184916


Homo sapiens

Features
Gene ID: ENSG00000184916
  
Biological name :JAG2
  
Synonyms : JAG2 / jagged 2 / Q9Y219
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105140981
Gene end: 105168824
  
Corresponding Affymetrix probe sets: 209784_s_at (Human Genome U133 Plus 2.0 Array)   32137_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328169
Ensembl peptide - ENSP00000328566
NCBI entrez gene - 3714     See in Manteia.
OMIM - 602570
RefSeq - NM_002226
RefSeq - NM_145159
RefSeq Peptide - NP_002217
RefSeq Peptide - NP_660142
swissprot - Q9Y219
Ensembl - ENSG00000184916
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jag2aENSDARG00000014246Danio rerio
 jag2bENSDARG00000021389Danio rerio
 JAG2ENSGALG00000011696Gallus gallus
 Jag2ENSMUSG00000002799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JAG1 / P78504 / jagged 1ENSG0000010138453
NOTCH2 / Q04721ENSG0000013425030
NOTCH3 / Q9UM47ENSG0000007418129
NOTCH1 / P46531ENSG0000014840029
NOTCH4 / Q99466ENSG0000020430126
SNED1 / Q8TER0 / sushi, nidogen and EGF like domains 1ENSG0000016280422
DLL1 / O00548 / delta like canonical Notch ligand 1ENSG0000019871920
DLL4 / Q9NR61 / delta like canonical Notch ligand 4ENSG0000012891718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR001774  Delta/Serrate/lag-2 (DSL) protein
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011651  Notch ligand, N-terminal domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026219  Jagged/Serrate protein
 IPR033108  Protein jagged-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0003016 respiratory system process IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007220 Notch receptor processing TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEP
 biological_processGO:0009912 auditory receptor cell fate commitment ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IEA
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030217 T cell differentiation IDA
 biological_processGO:0035333 Notch receptor processing, ligand-dependent TAS
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042492 gamma-delta T cell differentiation IEA
 biological_processGO:0045061 thymic T cell selection IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway ISS
 biological_processGO:1990134 epithelial cell apoptotic process involved in palatal shelf morphogenesis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134250 NOTCH2 / Q04721  / complex / reaction
 ENSG00000074181 NOTCH3 / Q9UM47  / reaction / complex
 ENSG00000137845 ADAM10 / O14672 / ADAM metallopeptidase domain 10  / reaction
 ENSG00000148400 NOTCH1 / P46531  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr