ENSG00000137845


Homo sapiens

Features
Gene ID: ENSG00000137845
  
Biological name :ADAM10
  
Synonyms : ADAM10 / ADAM metallopeptidase domain 10 / O14672
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.3
Gene start: 58588807
Gene end: 58749978
  
Corresponding Affymetrix probe sets: 202603_at (Human Genome U133 Plus 2.0 Array)   202604_x_at (Human Genome U133 Plus 2.0 Array)   214895_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391930
Ensembl peptide - ENSP00000481779
Ensembl peptide - ENSP00000456542
Ensembl peptide - ENSP00000453952
Ensembl peptide - ENSP00000452704
Ensembl peptide - ENSP00000452639
Ensembl peptide - ENSP00000260408
Ensembl peptide - ENSP00000386056
NCBI entrez gene - 102     See in Manteia.
OMIM - 602192
RefSeq - NM_001110
RefSeq - NM_001320570
RefSeq - XM_017021861
RefSeq Peptide - NP_001101
RefSeq Peptide - NP_001307499
swissprot - C9J9B4
swissprot - H3BS53
swissprot - O14672
swissprot - H0YNC5
swissprot - B5MC71
swissprot - A0A087WYG1
swissprot - A0A024R5U5
swissprot - H0YK32
swissprot - H0YK87
Ensembl - ENSG00000137845
  
Related genetic diseases (OMIM): 615537 - Reticulate acropigmentation of Kitamura, 615537
  615590 - {Alzheimer disease 18, susceptibility to}, 615590
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam10aENSDARG00000053468Danio rerio
 adam10bENSDARG00000015502Danio rerio
 ADAM10ENSGALG00000004212Gallus gallus
 Adam10ENSMUSG00000054693Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM17 / P78536 / ADAM metallopeptidase domain 17ENSG0000015169427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR027053  Disintegrin and metalloproteinase domain-containing protein 10
 IPR034025  ADAM10/ADAM17 catalytic domain
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development ISS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007162 negative regulation of cell adhesion NAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing TAS
 biological_processGO:0007229 integrin-mediated signaling pathway NAS
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010820 positive regulation of T cell chemotaxis IMP
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0035333 Notch receptor processing, ligand-dependent TAS
 biological_processGO:0042117 monocyte activation IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0051088 PMA-inducible membrane protein ectodomain proteolysis IMP
 biological_processGO:0051089 constitutive protein ectodomain proteolysis IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005798 Golgi-associated vesicle IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum IDA
 cellular_componentGO:0097197 tetraspanin-enriched microdomain IDA
 molecular_functionGO:0004175 endopeptidase activity ISS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding NAS
 molecular_functionGO:0005178 integrin binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Signaling by EGFR
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
Post-translational protein phosphorylation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108219 Q8NG11 / TSPAN14 / tetraspanin 14  / complex / reaction
 ENSG00000134250 NOTCH2 / Q04721  / reaction
 ENSG00000099282 O95858 / TSPAN15 / tetraspanin 15  / complex / reaction
 ENSG00000198719 DLL1 / O00548 / delta like canonical Notch ligand 1  / reaction
 ENSG00000101384 JAG1 / P78504 / jagged 1  / reaction
 ENSG00000148400 NOTCH1 / P46531  / reaction
 ENSG00000074181 NOTCH3 / Q9UM47  / reaction
 ENSG00000158457 Q86UF1 / TSPAN33 / tetraspanin 33  / complex / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction
 ENSG00000142192 APP / P05067 / amyloid beta precursor protein  / reaction
 ENSG00000168785 P62079 / TSPAN5 / tetraspanin 5  / complex / reaction
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction
 ENSG00000184916 JAG2 / Q9Y219 / jagged 2  / reaction
 ENSG00000128917 DLL4 / Q9NR61 / delta like canonical Notch ligand 4  / reaction






 

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