ENSDARG00000053468


Danio rerio

Features
Gene ID: ENSDARG00000053468
  
Biological name :adam10a
  
Synonyms : adam10a / ADAM metallopeptidase domain 10a
  
Possible biological names infered from orthology : ADAM10 / ADAM metallopeptidase domain 10 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672 / O35598
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 30406150
Gene end: 30492261
  
Corresponding Affymetrix probe sets: Dr.19510.1.S1_at (Zebrafish Array)   Dr.24387.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000090413
Ensembl peptide - ENSDARP00000142998
Ensembl peptide - ENSDARP00000142876
Ensembl peptide - ENSDARP00000141214
NCBI entrez gene - 566044     See in Manteia.
RefSeq - NM_001159314
RefSeq Peptide - NP_001152786
swissprot - A0A0R4IVX1
swissprot - A0A1D5NT24
swissprot - F1RA88
swissprot - A0A1D5NSQ9
ZFIN ID - ZDB-GENE-040917-2
Ensembl - ENSDARG00000053468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADAM10ENSGALG00000004212Gallus gallus
 ADAM10ENSG00000137845Homo sapiens
 Adam10ENSMUSG00000054693Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
adam10b / ADAM metallopeptidase domain 10b / ADAM10* / O14672* / ADAM metallopeptidase domain 10*ENSDARG0000001550256
si:ch1073-396h14.1ENSDARG0000005759027
adam17a / ADAM metallopeptidase domain 17a / ADAM17* / P78536* / Q9Z0F8* / ADAM metallopeptidase domain 17* / Disintegrin and metalloproteinase domain-containing protein 17 *ENSDARG0000004321326
adam17b / ADAM metallopeptidase domain 17b / ADAM17* / P78536* / Q9Z0F8* / ADAM metallopeptidase domain 17* / Disintegrin and metalloproteinase domain-containing protein 17 *ENSDARG0000009309326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR027053  Disintegrin and metalloproteinase domain-containing protein 10
 IPR034025  ADAM10/ADAM17 catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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