ENSG00000204301


Homo sapiens

Features
Gene ID: ENSG00000204301
  
Biological name :NOTCH4
  
Synonyms : NOTCH4 / Q99466
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.32
Gene start: 32194843
Gene end: 32224067
  
Corresponding Affymetrix probe sets: 205247_at (Human Genome U133 Plus 2.0 Array)   240786_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364163
NCBI entrez gene - 4855     See in Manteia.
OMIM - 164951
RefSeq - NM_004557
RefSeq Peptide - NP_004548
swissprot - A0A1U9X983
swissprot - Q99466
Ensembl - ENSG00000204301
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Notch4ENSMUSG00000015468Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOTCH1 / P46531ENSG0000014840042
NOTCH3 / Q9UM47ENSG0000007418141
NOTCH2 / Q04721ENSG0000013425041
SNED1 / Q8TER0 / sushi, nidogen and EGF like domains 1ENSG0000016280416
JAG2 / Q9Y219 / jagged 2ENSG0000018491616
JAG1 / P78504 / jagged 1ENSG0000010138415
DLL1 / O00548 / delta like canonical Notch ligand 1ENSG0000019871910
DLL4 / Q9NR61 / delta like canonical Notch ligand 4ENSG000001289178


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022355  Neurogenic locus Notch 4
 IPR035993  Notch-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001709 cell fate determination TAS
 biological_processGO:0001763 morphogenesis of a branching structure ISS
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0001944 vasculature development ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007220 Notch receptor processing TAS
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030097 hemopoiesis TAS
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0030879 mammary gland development IDA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0045596 negative regulation of cell differentiation NAS
 biological_processGO:0045602 negative regulation of endothelial cell differentiation ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0050793 regulation of developmental process IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity TAS


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128917 DLL4 / Q9NR61 / delta like canonical Notch ligand 4  / complex / reaction
 ENSG00000101384 JAG1 / P78504 / jagged 1  / reaction / complex
 ENSG00000013810 TACC3 / Q9Y6A5 / transforming acidic coiled-coil containing protein 3  / reaction / complex
 ENSG00000161021 MAML1 / Q92585 / mastermind like transcriptional coactivator 1  / complex / reaction
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000080815 PSEN1 / P49768 / presenilin 1  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / reaction / complex
 ENSG00000204301 NOTCH4 / Q99466  / complex
 ENSG00000143801 PSEN2 / P49810 / presenilin 2  / reaction
 ENSG00000101346 POFUT1 / Q9H488 / protein O-fucosyltransferase 1  / reaction
 ENSG00000196782 MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3  / reaction / complex
 ENSG00000184384 MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2  / complex / reaction






 

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