ENSG00000164924


Homo sapiens

Features
Gene ID: ENSG00000164924
  
Biological name :YWHAZ
  
Synonyms : P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta / YWHAZ
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.3
Gene start: 100916525
Gene end: 100953388
  
Corresponding Affymetrix probe sets: 200638_s_at (Human Genome U133 Plus 2.0 Array)   200639_s_at (Human Genome U133 Plus 2.0 Array)   200640_at (Human Genome U133 Plus 2.0 Array)   200641_s_at (Human Genome U133 Plus 2.0 Array)   214848_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395114
Ensembl peptide - ENSP00000398599
Ensembl peptide - ENSP00000430219
Ensembl peptide - ENSP00000430072
Ensembl peptide - ENSP00000430058
Ensembl peptide - ENSP00000429623
Ensembl peptide - ENSP00000429041
Ensembl peptide - ENSP00000428860
Ensembl peptide - ENSP00000428775
Ensembl peptide - ENSP00000428381
Ensembl peptide - ENSP00000416551
Ensembl peptide - ENSP00000309503
Ensembl peptide - ENSP00000379278
Ensembl peptide - ENSP00000379281
Ensembl peptide - ENSP00000379283
Ensembl peptide - ENSP00000379286
Ensembl peptide - ENSP00000379287
Ensembl peptide - ENSP00000379288
Ensembl peptide - ENSP00000394880
NCBI entrez gene - 7534     See in Manteia.
OMIM - 601288
RefSeq - XM_017013811
RefSeq - NM_001135699
RefSeq - NM_001135700
RefSeq - NM_001135701
RefSeq - NM_001135702
RefSeq - NM_003406
RefSeq - NM_145690
RefSeq - XM_005251061
RefSeq - XM_005251063
RefSeq - XM_017013810
RefSeq Peptide - NP_001129171
RefSeq Peptide - NP_001129172
RefSeq Peptide - NP_663723
RefSeq Peptide - NP_001129174
RefSeq Peptide - NP_003397
RefSeq Peptide - NP_001129173
swissprot - E5RIR4
swissprot - E5RGE1
swissprot - D0PNI1
swissprot - B7Z2E6
swissprot - B0AZS6
swissprot - H0YB80
swissprot - P63104
swissprot - E9PD24
swissprot - E7EX29
swissprot - E7EVZ2
swissprot - E7ESK7
Ensembl - ENSG00000164924
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YWHAZENSGALG00000031387Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaENSG0000016691387
YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSG0000013430880
YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaENSG0000012824575
YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaENSG0000017002775
SFN / P31947 / stratifinENSG0000017579371
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonENSG0000010895369


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0051683 establishment of Golgi localization IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0090168 Golgi reassembly IMP
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000169704 GP9 / P14770 / glycoprotein IX platelet  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000185245 GP1BA / P07359 / glycoprotein Ib platelet alpha subunit  / reaction / complex
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / reaction / complex
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex / reaction
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / reaction / complex
 ENSG00000164399 IL3 / P08700 / interleukin 3  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000113525 IL5 / P05113 / interleukin 5  / reaction / complex
 ENSG00000082898 XPO1 / O14980 / exportin 1  / reaction / complex
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / reaction / complex
 ENSG00000204301 NOTCH4 / Q99466  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000132359 Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2  / reaction / complex
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / reaction / complex
 ENSG00000088247 KHSRP / Q92945 / KH-type splicing regulatory protein  / complex
 ENSG00000100211 CBY1 / Q9Y3M2 / chibby family member 1, beta catenin antagonist  / reaction / complex
 ENSG00000203618 GP1BB / P13224 / glycoprotein Ib platelet beta subunit  / reaction / complex
 ENSG00000178732 GP5 / P40197 / glycoprotein V platelet  / reaction / complex






 

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