ENSG00000132359


Homo sapiens

Features
Gene ID: ENSG00000132359
  
Biological name :RAP1GAP2
  
Synonyms : Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.3
Gene start: 2755705
Gene end: 3037739
  
Corresponding Affymetrix probe sets: 213280_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000490321
Ensembl peptide - ENSP00000254695
Ensembl peptide - ENSP00000389824
Ensembl peptide - ENSP00000439688
Ensembl peptide - ENSP00000444890
NCBI entrez gene - 23108     See in Manteia.
RefSeq - XM_017024371
RefSeq - NM_001100398
RefSeq - NM_001330058
RefSeq - NM_015085
RefSeq - XM_011523742
RefSeq - XM_011523743
RefSeq - XM_011523744
RefSeq - XM_011523745
RefSeq - XM_017024370
RefSeq - XM_005256542
RefSeq - XM_006721477
RefSeq - XM_011523738
RefSeq - XM_011523739
RefSeq - XM_011523740
RefSeq - XM_011523741
RefSeq Peptide - NP_001093868
RefSeq Peptide - NP_001316987
RefSeq Peptide - NP_055900
swissprot - Q684P5
swissprot - A0A1B0GV05
Ensembl - ENSG00000132359
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rap1gap2aENSDARG00000061551Danio rerio
 rap1gap2bENSDARG00000074222Danio rerio
 RAP1GAP2ENSGALG00000033885Gallus gallus
 Q5SVL6ENSMUSG00000038807Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P47736 / RAP1GAP / RAP1 GTPase activating proteinENSG0000007686448
O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1ENSG0000019755530
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG0000010573830
Q9P2F8 / SIPA1L2 / signal induced proliferation associated 1 like 2ENSG0000011699129
SIPA1 / Q96FS4 / signal-induced proliferation-associated 1ENSG0000021344527
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG0000013689525
Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2ENSG0000018855914
Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1ENSG0000017437313
TSC2 / P49815 / TSC complex subunit 2ENSG0000010319712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR035974  Rap/Ran-GAP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IGI
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity EXP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Rap1 signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / reaction / complex
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction
 ENSG00000185532 PRKG1 / Q13976 / protein kinase, cGMP-dependent, type I  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / reaction






 

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