ENSG00000197555


Homo sapiens

Features
Gene ID: ENSG00000197555
  
Biological name :SIPA1L1
  
Synonyms : O43166 / signal induced proliferation associated 1 like 1 / SIPA1L1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.2
Gene start: 71320449
Gene end: 71741229
  
Corresponding Affymetrix probe sets: 202254_at (Human Genome U133 Plus 2.0 Array)   202255_s_at (Human Genome U133 Plus 2.0 Array)   237032_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452450
Ensembl peptide - ENSP00000450832
Ensembl peptide - ENSP00000452080
Ensembl peptide - ENSP00000351352
Ensembl peptide - ENSP00000370630
Ensembl peptide - ENSP00000440682
NCBI entrez gene - 26037     See in Manteia.
OMIM - 617504
RefSeq - XM_017021200
RefSeq - XM_017021188
RefSeq - XM_017021189
RefSeq - XM_017021190
RefSeq - XM_017021191
RefSeq - XM_017021192
RefSeq - XM_017021193
RefSeq - XM_017021194
RefSeq - XM_017021195
RefSeq - XM_017021196
RefSeq - XM_017021197
RefSeq - XM_017021198
RefSeq - XM_017021199
RefSeq - NM_001284245
RefSeq - NM_001284246
RefSeq - NM_001284247
RefSeq - NM_001354285
RefSeq - NM_015556
RefSeq - XM_005267516
RefSeq - XM_006720111
RefSeq - XM_011536630
RefSeq - XM_011536631
RefSeq - XM_011536632
RefSeq - XM_011536635
RefSeq - XM_011536638
RefSeq - XM_017021159
RefSeq - XM_017021160
RefSeq - XM_017021161
RefSeq - XM_017021162
RefSeq - XM_017021163
RefSeq - XM_017021164
RefSeq - XM_017021165
RefSeq - XM_017021166
RefSeq - XM_017021167
RefSeq - XM_017021168
RefSeq - XM_017021169
RefSeq - XM_017021170
RefSeq - XM_017021171
RefSeq - XM_017021172
RefSeq - XM_017021173
RefSeq - XM_017021174
RefSeq - XM_017021175
RefSeq - XM_017021176
RefSeq - XM_017021177
RefSeq - XM_017021178
RefSeq - XM_017021179
RefSeq - XM_017021180
RefSeq - XM_017021181
RefSeq - XM_017021182
RefSeq - XM_017021183
RefSeq - XM_017021184
RefSeq - XM_017021185
RefSeq - XM_017021186
RefSeq - XM_017021187
RefSeq Peptide - NP_001271175
RefSeq Peptide - NP_001271176
RefSeq Peptide - NP_001341214
RefSeq Peptide - NP_001341215
RefSeq Peptide - NP_056371
RefSeq Peptide - NP_001341216
RefSeq Peptide - NP_001341217
RefSeq Peptide - NP_001271174
swissprot - F5GYF8
swissprot - H0YJY2
swissprot - O43166
swissprot - G3V4Z3
Ensembl - ENSG00000197555
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sipa1l1ENSDARG00000020134Danio rerio
 SIPA1L1ENSGALG00000009381Gallus gallus
 Q8C0T5ENSMUSG00000042700Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9P2F8 / SIPA1L2 / signal induced proliferation associated 1 like 2ENSG0000011699151
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG0000010573847
SIPA1 / Q96FS4 / signal-induced proliferation-associated 1ENSG0000021344525
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG0000013689514
Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2ENSG0000018855912
Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1ENSG0000017437312
Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2ENSG0000013235912
P47736 / RAP1GAP / RAP1 GTPase activating proteinENSG0000007686411
TSC2 / P49815 / TSC complex subunit 2ENSG000001031979


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR001478  PDZ domain
 IPR011993  PH-like domain superfamily
 IPR021818  Signal-induced proliferation-associated 1-like protein, C-terminal
 IPR030770  Signal-induced proliferation-associated 1-like protein 1
 IPR035974  Rap/Ran-GAP superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis ISS
 biological_processGO:0090630 activation of GTPase activity ISS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / reaction / complex
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / reaction / complex
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction / complex
 ENSG00000163110 PDLIM5 / Q96HC4 / PDZ and LIM domain 5  / reaction / complex
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction / complex






 

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