ENSG00000174373


Homo sapiens

Features
Gene ID: ENSG00000174373
  
Biological name :RALGAPA1
  
Synonyms : Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q13.2
Gene start: 35538352
Gene end: 35809304
  
Corresponding Affymetrix probe sets: 1566269_at (Human Genome U133 Plus 2.0 Array)   1566271_x_at (Human Genome U133 Plus 2.0 Array)   1566272_at (Human Genome U133 Plus 2.0 Array)   213049_at (Human Genome U133 Plus 2.0 Array)   214855_s_at (Human Genome U133 Plus 2.0 Array)   215162_at (Human Genome U133 Plus 2.0 Array)   234923_at (Human Genome U133 Plus 2.0 Array)   235524_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451877
Ensembl peptide - ENSP00000451133
Ensembl peptide - ENSP00000490119
Ensembl peptide - ENSP00000302647
Ensembl peptide - ENSP00000371803
Ensembl peptide - ENSP00000374348
Ensembl peptide - ENSP00000450574
NCBI entrez gene - 253959     See in Manteia.
OMIM - 608884
RefSeq - XM_017021147
RefSeq - XM_006720098
RefSeq - XM_006720099
RefSeq - XM_006720100
RefSeq - XM_006720101
RefSeq - XM_006720102
RefSeq - XM_006720103
RefSeq - XM_011536615
RefSeq - XM_011536616
RefSeq - XM_017021141
RefSeq - XM_017021142
RefSeq - XM_017021143
RefSeq - XM_017021144
RefSeq - XM_017021145
RefSeq - NM_001283043
RefSeq - NM_001283044
RefSeq - NM_001330075
RefSeq - NM_001346243
RefSeq - NM_001346246
RefSeq - NM_001346248
RefSeq - NM_014990
RefSeq - NM_194301
RefSeq - XM_005267491
RefSeq - XM_005267492
RefSeq - XM_005267493
RefSeq Peptide - NP_001317004
RefSeq Peptide - NP_055805
RefSeq Peptide - NP_919277
RefSeq Peptide - NP_001269972
RefSeq Peptide - NP_001269973
RefSeq Peptide - NP_001333172
RefSeq Peptide - NP_001333174
RefSeq Peptide - NP_001333175
RefSeq Peptide - NP_001333177
swissprot - H0YJB5
swissprot - Q6GYQ0
swissprot - A0A1B0GUI1
swissprot - H0YJ04
Ensembl - ENSG00000174373
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ralgapa1ENSDARG00000076889Danio rerio
 RALGAPA1ENSGALG00000010088Gallus gallus
 Q6GYP7ENSMUSG00000021027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2ENSG0000018855941
TSC2 / P49815 / TSC complex subunit 2ENSG0000010319713
O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1ENSG000001975559
Q9P2F8 / SIPA1L2 / signal induced proliferation associated 1 like 2ENSG000001169918
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG000001057388
SIPA1 / Q96FS4 / signal-induced proliferation-associated 1ENSG000002134456
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG000001368955
Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2ENSG000001323594
P47736 / RAP1GAP / RAP1 GTPase activating proteinENSG000000768644


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR016024  Armadillo-type fold
 IPR027107  Tuberin/Ral GTPase-activating protein subunit alpha
 IPR035974  Rap/Ran-GAP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0090630 activation of GTPase activity ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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