ENSG00000188559


Homo sapiens

Features
Gene ID: ENSG00000188559
  
Biological name :RALGAPA2
  
Synonyms : Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p11.23
Gene start: 20389552
Gene end: 20712488
  
Corresponding Affymetrix probe sets: 225499_at (Human Genome U133 Plus 2.0 Array)   231826_at (Human Genome U133 Plus 2.0 Array)   232500_at (Human Genome U133 Plus 2.0 Array)   234314_at (Human Genome U133 Plus 2.0 Array)   239660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481660
Ensembl peptide - ENSP00000202677
Ensembl peptide - ENSP00000388695
Ensembl peptide - ENSP00000400085
NCBI entrez gene - 57186     See in Manteia.
RefSeq - XM_017027976
RefSeq - XM_011529311
RefSeq - XM_017027972
RefSeq - XM_017027973
RefSeq - XM_017027974
RefSeq - XM_017027975
RefSeq - NM_020343
RefSeq - XM_005260768
RefSeq - XM_006723598
RefSeq - XM_006723599
RefSeq - XM_011529309
RefSeq - XM_011529310
RefSeq Peptide - NP_065076
swissprot - H7BZA8
swissprot - H7C1F9
swissprot - A0A087WYA8
swissprot - Q2PPJ7
Ensembl - ENSG00000188559
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ralgapa2ENSDARG00000005861Danio rerio
 ENSGALG00000044730Gallus gallus
 ENSGALG00000032964Gallus gallus
 A3KGS3ENSMUSG00000037110Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1ENSG0000017437355
TSC2 / P49815 / TSC complex subunit 2ENSG0000010319716
O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1ENSG0000019755511
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG0000010573811
Q9P2F8 / SIPA1L2 / signal induced proliferation associated 1 like 2ENSG0000011699111
SIPA1 / Q96FS4 / signal-induced proliferation-associated 1ENSG000002134458
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG000001368957
P47736 / RAP1GAP / RAP1 GTPase activating proteinENSG000000768646
Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2ENSG000001323595


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR027107  Tuberin/Ral GTPase-activating protein subunit alpha
 IPR035974  Rap/Ran-GAP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0090630 activation of GTPase activity ISS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170471 Q86X10 / RALGAPB / Ral GTPase activating protein non-catalytic beta subunit  / complex
 ENSG00000105221 AKT2 / P31751 / AKT serine/threonine kinase 2  / reaction






 

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