ENSG00000076864


Homo sapiens

Features
Gene ID: ENSG00000076864
  
Biological name :RAP1GAP
  
Synonyms : P47736 / RAP1GAP / RAP1 GTPase activating protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.12
Gene start: 21596215
Gene end: 21669363
  
Corresponding Affymetrix probe sets: 203911_at (Human Genome U133 Plus 2.0 Array)   210618_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431364
Ensembl peptide - ENSP00000392717
Ensembl peptide - ENSP00000434033
Ensembl peptide - ENSP00000441661
Ensembl peptide - ENSP00000290101
Ensembl peptide - ENSP00000315420
Ensembl peptide - ENSP00000363893
Ensembl peptide - ENSP00000363895
Ensembl peptide - ENSP00000363897
NCBI entrez gene - 5909     See in Manteia.
OMIM - 600278
RefSeq - XM_017001991
RefSeq - XM_017001978
RefSeq - XM_017001979
RefSeq - XM_017001980
RefSeq - XM_017001981
RefSeq - XM_017001982
RefSeq - XM_017001983
RefSeq - XM_017001984
RefSeq - XM_017001985
RefSeq - XM_017001986
RefSeq - XM_017001987
RefSeq - XM_017001988
RefSeq - XM_017001989
RefSeq - XM_017001990
RefSeq - NM_001145657
RefSeq - NM_001145658
RefSeq - NM_001330383
RefSeq - NM_001350527
RefSeq - NM_002885
RefSeq - XM_005245955
RefSeq - XM_006710804
RefSeq - XM_006710805
RefSeq - XM_017001965
RefSeq - XM_017001966
RefSeq - XM_017001967
RefSeq - XM_017001968
RefSeq - XM_017001969
RefSeq - XM_017001970
RefSeq - XM_017001971
RefSeq - XM_017001972
RefSeq - XM_017001973
RefSeq - XM_017001974
RefSeq - XM_017001975
RefSeq - XM_017001976
RefSeq - XM_017001977
RefSeq Peptide - NP_001139129
RefSeq Peptide - NP_001139130
RefSeq Peptide - NP_001317312
RefSeq Peptide - NP_001337456
RefSeq Peptide - NP_002876
swissprot - Q5T3T1
swissprot - A0A0A0MQY8
swissprot - A0A024RAB5
swissprot - X6R8W7
swissprot - F2Z357
swissprot - J3KPC5
swissprot - P47736
swissprot - Q5T3T0
Ensembl - ENSG00000076864
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rap1gapENSDARG00000056554Danio rerio
 si:dkey-166d12.2ENSDARG00000053272Danio rerio
 RAP1GAP1ENSGALG00000014701Gallus gallus
 A2ALS5ENSMUSG00000041351Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2ENSG0000013235947
Q9P2F8 / SIPA1L2 / signal induced proliferation associated 1 like 2ENSG0000011699129
O60292 / SIPA1L3 / signal induced proliferation associated 1 like 3ENSG0000010573828
O43166 / SIPA1L1 / signal induced proliferation associated 1 like 1ENSG0000019755528
GARNL3 / Q5VVW2 / GTPase activating Rap/RanGAP domain like 3ENSG0000013689524
SIPA1 / Q96FS4 / signal-induced proliferation-associated 1ENSG0000021344523
Q6GYQ0 / RALGAPA1 / Ral GTPase activating protein catalytic alpha subunit 1ENSG0000017437314
Q2PPJ7 / RALGAPA2 / Ral GTPase activating protein catalytic alpha subunit 2ENSG0000018855914
TSC2 / P49815 / TSC complex subunit 2ENSG0000010319711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR003109  GoLoco motif
 IPR035974  Rap/Ran-GAP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:1903697 negative regulation of microvillus assembly IMP
 biological_processGO:1904425 negative regulation of GTP binding IEA
 biological_processGO:1904442 negative regulation of thyroid gland epithelial cell proliferation IEA
 biological_processGO:1990792 cellular response to glial cell derived neurotrophic factor IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003924 GTPase activity NAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IPI
 molecular_functionGO:0030695 GTPase regulator activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Rap1 signalling
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125650 PSPN / O60542 / persephin  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / reaction / complex
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / reaction / complex
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / reaction / complex
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / reaction / complex
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction






 

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