Manteia

ENSG00000146013

Homo sapiens

Features

Gene ID:	ENSG00000146013

Biological name :	GFRA3

Synonyms :	GDNF family receptor alpha 3 / GFRA3 / O60609

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	5
Strand:	-1
Band:	q31.2
Gene start:	138252379
Gene end:	138274671

Corresponding Affymetrix probe sets:	214479_at (Human Genome U133 Plus 2.0 Array) 229936_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000274721 Ensembl peptide - ENSP00000367613 NCBI entrez gene - 2676 See in Manteia. OMIM - 605710 RefSeq - NM_001496 RefSeq Peptide - NP_001487 swissprot - O60609 swissprot - K9J968 Ensembl - ENSG00000146013

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gfra3	ENSDARG00000087704	Danio rerio
GFRA3	ENSGALG00000007620	Gallus gallus
Gfra3	ENSMUSG00000024366	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
GFRA1 / P56159 / GDNF family receptor alpha 1	ENSG00000151892	33
GFRA2 / O00451 / GDNF family receptor alpha 2	ENSG00000168546	32
GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4	ENSG00000125861	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR003438	Glial cell line-derived neurotrophic factor receptor
IPR003505	Glial cell line-derived neurotrophic factor receptor, alpha 3
IPR016017	GDNF/GAS1
IPR037193	GDNF receptor alpha

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0001764	neuron migration	IEA
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007399	nervous system development	TAS
biological_process	GO:0007411	axon guidance	TAS
biological_process	GO:0007422	peripheral nervous system development	TAS
biological_process	GO:0048485	sympathetic nervous system development	IEA
biological_process	GO:0048666	neuron development	IEA
biological_process	GO:0065009	regulation of molecular function	IEA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0019898	extrinsic component of membrane	TAS
cellular_component	GO:0031225	anchored component of membrane	IEA
molecular_function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS
molecular_function	GO:0005102	signaling receptor binding	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008046	axon guidance receptor activity	IEA

Pathways (from Reactome)

Pathway description

RAF/MAP kinase cascade

RET signaling

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000125650	PSPN / O60542 / persephin	/ complex / reaction
ENSG00000109458	GAB1 / Q13480 / GRB2 associated binding protein 1	/ complex
ENSG00000141738	GRB7 / Q14451 / growth factor receptor bound protein 7	/ complex / reaction
ENSG00000168546	GFRA2 / O00451 / GDNF family receptor alpha 2	/ reaction / complex
ENSG00000171119	NRTN / Q99748 / neurturin	/ reaction / complex
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex
ENSG00000033327	GAB2 / Q9UQC2 / GRB2 associated binding protein 2	/ complex
ENSG00000076864	P47736 / RAP1GAP / RAP1 GTPase activating protein	/ reaction / complex
ENSG00000179295	PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11	/ complex / reaction
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ complex
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ reaction / complex
ENSG00000146013	GFRA3 / O60609 / GDNF family receptor alpha 3	/ reaction / complex
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ reaction / complex
ENSG00000168621	GDNF / P39905 / glial cell derived neurotrophic factor	/ complex / reaction
ENSG00000166225	FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2	/ complex / reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex
ENSG00000117407	ARTN / Q5T4W7 / artemin	/ reaction / complex
ENSG00000171608	O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	/ complex
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000125861	GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4	/ reaction / complex
ENSG00000165731	RET / P07949 / ret proto-oncogene	/ reaction / complex
ENSG00000106070	GRB10 / Q13322 / growth factor receptor bound protein 10	/ reaction / complex
ENSG00000151892	GFRA1 / P56159 / GDNF family receptor alpha 1	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr