ENSG00000106070


Homo sapiens

Features
Gene ID: ENSG00000106070
  
Biological name :GRB10
  
Synonyms : GRB10 / growth factor receptor bound protein 10 / Q13322
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p12.1
Gene start: 50590063
Gene end: 50793462
  
Corresponding Affymetrix probe sets: 209409_at (Human Genome U133 Plus 2.0 Array)   209410_s_at (Human Genome U133 Plus 2.0 Array)   210999_s_at (Human Genome U133 Plus 2.0 Array)   215248_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495397
Ensembl peptide - ENSP00000495341
Ensembl peptide - ENSP00000496245
Ensembl peptide - ENSP00000338543
Ensembl peptide - ENSP00000349818
Ensembl peptide - ENSP00000381790
Ensembl peptide - ENSP00000381793
Ensembl peptide - ENSP00000385046
Ensembl peptide - ENSP00000385189
Ensembl peptide - ENSP00000385366
Ensembl peptide - ENSP00000385544
Ensembl peptide - ENSP00000385748
Ensembl peptide - ENSP00000385770
Ensembl peptide - ENSP00000410920
Ensembl peptide - ENSP00000413023
Ensembl peptide - ENSP00000493728
NCBI entrez gene - 2887     See in Manteia.
OMIM - 601523
RefSeq - XM_017012068
RefSeq - XM_017012058
RefSeq - XM_017012059
RefSeq - XM_017012060
RefSeq - XM_017012061
RefSeq - XM_017012062
RefSeq - XM_017012063
RefSeq - XM_017012064
RefSeq - XM_017012065
RefSeq - XM_017012066
RefSeq - XM_017012067
RefSeq - NM_001001549
RefSeq - NM_001001550
RefSeq - NM_001001555
RefSeq - NM_001350814
RefSeq - NM_001350816
RefSeq - NM_005311
RefSeq - XM_011515304
RefSeq - XM_011515312
RefSeq - XM_011515316
RefSeq - XM_011515323
RefSeq - XM_017012029
RefSeq - XM_017012030
RefSeq - XM_017012031
RefSeq - XM_017012032
RefSeq - XM_017012033
RefSeq - XM_017012034
RefSeq - XM_017012035
RefSeq - XM_017012036
RefSeq - XM_017012037
RefSeq - XM_017012038
RefSeq - XM_017012039
RefSeq - XM_017012040
RefSeq - XM_017012041
RefSeq - XM_017012042
RefSeq - XM_017012043
RefSeq - XM_017012044
RefSeq - XM_017012045
RefSeq - XM_017012046
RefSeq - XM_017012047
RefSeq - XM_017012048
RefSeq - XM_017012049
RefSeq - XM_017012050
RefSeq - XM_017012051
RefSeq - XM_017012052
RefSeq - XM_017012053
RefSeq - XM_017012054
RefSeq - XM_017012055
RefSeq - XM_017012056
RefSeq - XM_017012057
RefSeq Peptide - NP_001001549
RefSeq Peptide - NP_001001550
RefSeq Peptide - NP_001001555
RefSeq Peptide - NP_001337745
RefSeq Peptide - NP_005302
RefSeq Peptide - NP_001337743
RefSeq Peptide - NP_001337744
swissprot - Q13322
swissprot - H7C3B9
swissprot - C9JTW6
Ensembl - ENSG00000106070
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grb10aENSDARG00000002013Danio rerio
 grb10bENSDARG00000035308Danio rerio
 GRB10ENSGALG00000013100Gallus gallus
 Grb10ENSMUSG00000020176Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB14 / Q14449 / growth factor receptor bound protein 14ENSG0000011529050
GRB7 / Q14451 / growth factor receptor bound protein 7ENSG0000014173848
RAPH1 / Q70E73 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1ENSG0000017316624
Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting proteinENSG0000007742023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035036  Growth factor receptor-bound protein 10
 IPR035037  Grb10, SH2
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0046325 negative regulation of glucose import ISS
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005158 insulin receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
IRS activation
Signal attenuation
Insulin receptor signalling cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000254647 INS / P01308 / insulin  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex / reaction
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / reaction / complex
 ENSG00000171105 INSR / P06213 / insulin receptor  / reaction / complex
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / reaction / complex
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000125650 PSPN / O60542 / persephin  / reaction / complex






 

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