ENSMUSG00000020176


Mus musculus

Features
Gene ID: ENSMUSG00000020176
  
Biological name :Grb10
  
Synonyms : Grb10 / Growth factor receptor-bound protein 10 / Q60760
  
Possible biological names infered from orthology : Q13322
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 11930508
Gene end: 12038683
  
Corresponding Affymetrix probe sets: 10384398 (MoGene1.0st)   1425457_a_at (Mouse Genome 430 2.0 Array)   1425458_a_at (Mouse Genome 430 2.0 Array)   1430164_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091011
Ensembl peptide - ENSMUSP00000115160
Ensembl peptide - ENSMUSP00000119344
Ensembl peptide - ENSMUSP00000118350
Ensembl peptide - ENSMUSP00000105280
Ensembl peptide - ENSMUSP00000105281
NCBI entrez gene - 14783     See in Manteia.
MGI - MGI:103232
RefSeq - XM_011243664
RefSeq - XM_006514529
RefSeq - NM_001177629
RefSeq - NM_010345
RefSeq Peptide - NP_034475
RefSeq Peptide - NP_001171100
swissprot - Q5SUW0
swissprot - Q5SUW3
swissprot - Q60760
swissprot - B1ATS8
swissprot - B1ATS7
Ensembl - ENSMUSG00000020176
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grb10aENSDARG00000002013Danio rerio
 grb10bENSDARG00000035308Danio rerio
 GRB10ENSGALG00000013100Gallus gallus
 GRB10ENSG00000106070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grb14 / Q9JLM9 / Growth factor receptor-bound protein 14 / Q14449*ENSMUSG0000002688847
Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*ENSMUSG0000001931245
Raph1 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 / Q70E73*ENSMUSG0000002601421
Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*ENSMUSG0000002678621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035036  Growth factor receptor-bound protein 10
 IPR035037  Grb10, SH2
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0042326 negative regulation of phosphorylation IDA
 biological_processGO:0045719 negative regulation of glycogen biosynthetic process TAS
 biological_processGO:0046325 negative regulation of glucose import IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IPI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IPI
 molecular_functionGO:0005158 insulin receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
IRS activation
Signal attenuation
Insulin receptor signalling cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0003397 increased muscle weight "greater than average muscle weight" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004199 enlarged fetal size "larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Rxrbtm1Mma/Rxrbtm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shhtm1Amc/Shhtm2Amc,Tg(Thy1-cre)703Vaw/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0009119 increased brown fat cell size "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0009702 increased birth body size "increase in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Grb10Gt(Betageo)1Ward/Grb10+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

 MP:0020520 whitened brown adipose tissue morphology "brown adipose tissue displays a morphology more closely resembling white adipose tissue (eg. unilocular lipid droplets, decreased lipid droplet numbers)" [MGI:mperry, PMID:24703692]
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Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grb10tm1.1Fliu/Grb10tm1.1Fliu,Tg(Adipoq-cre)#Pesch/0
Genetic Background: involves: 129S/SvEv * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000005534 Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / reaction / complex
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / reaction / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction






 

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