ENSMUSG00000022144


Mus musculus

Features
Gene ID: ENSMUSG00000022144
  
Biological name :Gdnf
  
Synonyms : Gdnf / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P48540
  
Possible biological names infered from orthology : glial cell derived neurotrophic factor / P39905
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 7810846
Gene end: 7837575
  
Corresponding Affymetrix probe sets: 10422844 (MoGene1.0st)   1419080_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022744
NCBI entrez gene - 14573     See in Manteia.
MGI - MGI:107430
RefSeq - NM_001301357
RefSeq - NM_010275
RefSeq - NM_001301332
RefSeq - NM_001301333
RefSeq Peptide - NP_001288261
RefSeq Peptide - NP_001288262
RefSeq Peptide - NP_001288286
RefSeq Peptide - NP_034405
swissprot - P48540
Ensembl - ENSMUSG00000022144
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdnfaENSDARG00000039959Danio rerio
 gdnfbENSDARG00000103764Danio rerio
 GDNFENSGALG00000003716Gallus gallus
 GDNFENSG00000168621Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrtn / P97463 / Neurturin / Q99748*ENSMUSG0000003948123
Artn / Q9Z0L2 / Artemin / Q5T4W7*ENSMUSG0000002853922
Pspn / persephin / O60542*ENSMUSG0000000266419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR016649  Glial cell line-derived neurotrophic factor
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001657 ureteric bud development IGI
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001759 organ induction IGI
 biological_processGO:0001941 postsynaptic membrane organization IDA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021784 postganglionic parasympathetic fiber development IMP
 biological_processGO:0030432 peristalsis IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032770 positive regulation of monooxygenase activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0051584 regulation of dopamine uptake involved in synaptic transmission IEA
 biological_processGO:0060676 ureteric bud formation IMP
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IDA
 biological_processGO:0072107 positive regulation of ureteric bud formation IEA
 biological_processGO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IMP
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005576 extracellular region ISO
 molecular_functionGO:0005160 transforming growth factor beta receptor binding TAS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm1Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm2Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8tm1Lfr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdnftm1Rosl/Gdnf+,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129S2/SvPas

 MP:0000836 abnormal substantia nigra morphology "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gdnftm1Bbd/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gdnftm1Bbd/Gdnftm1.1Neas,Egr3tm1(cre)Mod/Egr3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gdnftm1.1Neas/Gdnftm1.1Neas,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gdnftm1Rosl/Gdnf+,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Bidtm1Sjk/Bidtm1Sjk,Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001047 abnormal enteric cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter and innervate the esophagus, stomach, small and large bowel" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0001048 absent enteric neurons "missing neurons that innervate the esophagus, stomach, small and large bowel" [Principles of Neural Science:ISBN 0-8385-8034-3, J:49471]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: B6.129-Gfra1tm1Rosl

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8tm1Lfr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0002827 abnormal renal corpuscle "anomalous structure or development of either Bowman s capsules and/or the glomeruli contained therein" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0002955 increased compensatory renal growth "increased additional growth of a kidney upon removal of the other kidney through surgery or disease" [RGD:Rat Genome Database submission]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Rosl/Gdnf+,Itga8tm1Lfr/Itga8tm1Lfr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Spry1tm1.1Jdli/Spry1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0003268 chronic constipation "prolonged or long-term difficulty in evacuation of fecal matter " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Gdnftm1Rosl/Gdnf+,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003307 pyloric stenosis "a narrowing of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003437 abnormal carotid body morphology "any malformation in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, monikat:Monika Tomczuk, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0003604 single kidney 
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Allelic Composition: Gdnftm1Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm2Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Gdnftm1Rosl/Gdnf+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0004103 abnormal ventral striatum morphology "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

Allelic Composition: Gdnftm1(cre/ERT2)Cos/Gdnf+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gdnftm1Rosl/Gdnf+,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0006100 abnormal tegmentum morphology "any structural alterations or malfunction of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0009511 distended stomach "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0009684 abnormal spinal cord lateral motor column morphology "any structural anomaly of the subclasses of motor neurons which innervate muscles in the limb; motor neurons in the lateral motor column are further organized into pools, each of which innervates a specific muscle in the limb" [PMID:8895454 "Tanabe Y, Jessell TM Diversity and pattern in the developing spinal cord. Science. 1996 Nov 15;274(5290):1115-23."]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0010800 abnormal submucous nerve plexus morphology "any structural anomaly of the gangliated plexus of unmyelinated nerve fibers that ramify the stomach and intestinal submucosa" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0010801 abnormal myenteric nerve plexus morphology "any structural anomaly of the plexus of unmyelinated nerve fibers and postganglionic autonomic cell bodies lying in the muscular coat of the esophagus, stomach and intestines that communicate with the submucosal, subserosal and enteric plexuses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
Show

Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm1Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm2Bbd/Gdnf+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnftm1Lmgd
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011359 decreased glomerular capillary number "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [MGI:csmith]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011753 decreased podocyte number "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: B6.129-Gdnftm1Lmgd

 MP:0011881 distended duodenum "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [MGI:Colin_McKerlie]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gdnftm2Bbd/Gdnftm2Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020491 abnormal ovary topology "any anomaly in the position of the ovary in relation to other structures" [MGI:smb]
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Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex / reaction
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / reaction / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / complex / reaction






 

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