ENSMUSG00000022103


Mus musculus

Features
Gene ID: ENSMUSG00000022103
  
Biological name :Gfra2
  
Synonyms : GDNF family receptor alpha-2 / Gfra2 / O08842
  
Possible biological names infered from orthology : O00451
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 70890120
Gene end: 70979838
  
Corresponding Affymetrix probe sets: 10416340 (MoGene1.0st)   1423007_a_at (Mouse Genome 430 2.0 Array)   1425578_a_at (Mouse Genome 430 2.0 Array)   1425579_at (Mouse Genome 430 2.0 Array)   1433716_x_at (Mouse Genome 430 2.0 Array)   1459847_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022699
Ensembl peptide - ENSMUSP00000153937
Ensembl peptide - ENSMUSP00000154391
NCBI entrez gene - 14586     See in Manteia.
MGI - MGI:1195462
RefSeq - NM_001302095
RefSeq - NM_001302094
RefSeq - NM_008115
RefSeq Peptide - NP_001289023
RefSeq Peptide - NP_001289024
RefSeq Peptide - NP_032141
swissprot - O08842
Ensembl - ENSMUSG00000022103
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfra2aENSDARG00000042723Danio rerio
 gfra2bENSDARG00000044015Danio rerio
 GFRA2ENSGALG00000032856Gallus gallus
 GFRA2ENSG00000168546Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*ENSMUSG0000002508947
Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*ENSMUSG0000002436630
Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*ENSMUSG0000002731623


Protein motifs (from Interpro)
Interpro ID Name
 IPR003438  Glial cell line-derived neurotrophic factor receptor
 IPR003504  Glial cell line-derived neurotrophic factor receptor alpha 2
 IPR016017  GDNF/GAS1
 IPR017372  Glial cell line-derived neurotrophic factor receptor, alpha 1/2
 IPR037193  GDNF receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IGI
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0031953 negative regulation of protein autophosphorylation IEA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
 biological_processGO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0016167 glial cell-derived neurotrophic factor receptor activity IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000392 accelerated hair follicle regression "quicker than average length of time for onset of catagen phase of the cyclic transformation of the hair follicle" [J:65034]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gfra2tm1Msa/Gfra2tm1Msa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001036 small submandibular ganglion "reduced size of the small parasympathetic ganglion of the lingual nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53284]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001037 abnormal parasympathethetic neuron morphology "malformed or absent neurons of the autonomic nervous system that are responsible for innervation of smooth muscle, cardiac muscle and glands" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Gfra2tm1Msa/Gfra2tm1Msa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001500 reduced kindling behavior "fewer epileptic episodes induced by daily sub threshold electrical brain stimulation" [J:45446]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004141 abnormal enteroendocrine cell morphology "malformation of the somatostatin and gastrin secreting epithelial cells present throughout the epithelium of the digestive tract" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
Show

Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008313 abnormal parasympathetic postganglionic fiber "any structural anomaly of any or all of the cholinergic axonal fibers projecting from a parasympathetic ganglion to an effector organ" [MESH:A08.663.542.100.700, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / reaction / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / reaction / complex
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / reaction / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr