ENSMUSG00000025089


Mus musculus

Features
Gene ID: ENSMUSG00000025089
  
Biological name :Gfra1
  
Synonyms : GDNF family receptor alpha-1 / Gfra1 / P97785
  
Possible biological names infered from orthology : P56159
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: D2
Gene start: 58235604
Gene end: 58455909
  
Corresponding Affymetrix probe sets: 10468722 (MoGene1.0st)   1421973_at (Mouse Genome 430 2.0 Array)   1439015_at (Mouse Genome 430 2.0 Array)   1450440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120058
Ensembl peptide - ENSMUSP00000130128
Ensembl peptide - ENSMUSP00000123022
Ensembl peptide - ENSMUSP00000122810
Ensembl peptide - ENSMUSP00000121447
Ensembl peptide - ENSMUSP00000120333
Ensembl peptide - ENSMUSP00000026076
Ensembl peptide - ENSMUSP00000115239
Ensembl peptide - ENSMUSP00000117196
NCBI entrez gene - 14585     See in Manteia.
MGI - MGI:1100842
RefSeq - XM_006526685
RefSeq - XM_006526684
RefSeq - XM_006526683
RefSeq - XM_006526682
RefSeq - NM_001285457
RefSeq - XM_006526681
RefSeq - NM_010279
RefSeq Peptide - NP_001272386
RefSeq Peptide - NP_034409
swissprot - P97785
swissprot - D6RDD4
swissprot - A0A1C7ZN00
swissprot - D3YUD5
swissprot - D3YWL3
swissprot - D3Z3C9
Ensembl - ENSMUSG00000025089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfra1aENSDARG00000099732Danio rerio
 gfra1bENSDARG00000102564Danio rerio
 GFRA1ENSGALG00000009173Gallus gallus
 GFRA1ENSG00000151892Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*ENSMUSG0000002210347
Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*ENSMUSG0000002436628
Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*ENSMUSG0000002731621


Protein motifs (from Interpro)
Interpro ID Name
 IPR003438  Glial cell line-derived neurotrophic factor receptor
 IPR003503  Glial cell line-derived neurotrophic factor receptor, alpha 1
 IPR016017  GDNF/GAS1
 IPR017372  Glial cell line-derived neurotrophic factor receptor, alpha 1/2
 IPR037193  GDNF receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hs6st1tm1Kkm/Hs6st1tm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C3H/He

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hs6st1tm1Kkm/Hs6st1tm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C3H/He

 MP:0000392 accelerated hair follicle regression "quicker than average length of time for onset of catagen phase of the cyclic transformation of the hair follicle" [J:65034]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

Allelic Composition: Gfra1tm2.1Jmi/Gfra1tm2.1Jmi
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gfra1tm2Jmi/Gfra1tm3Jmi,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gfra1tm1(cre/ERT2)Sjn/Gfra1tm1(cre/ERT2)Sjn
Genetic Background: involves: C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Rettm1Heno/Rettm1Heno
Genetic Background: Not Specified

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gfra1tm2Jmi/Gfra1tm2Jmi,Mnx1tm4(cre)Tmj/Mnx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Gfra1tm3Jmi/Gfra1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0001033 abnormal parasympatheic system morphology "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and regulates homeostasis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53284]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Egr3tm1Jmi/Egr3tm1Jmi,Gfra1tm3Jmi/Gfra1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Gfra1tm3Jmi/Gfra1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

Allelic Composition: Gfra1tm1Jmi/Gfra1tm2Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Gfra1tm2.1Jmi/Gfra1tm2.1Jmi
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm1Jmi/Gfra1tm2Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001048 absent enteric neurons "missing neurons that innervate the esophagus, stomach, small and large bowel" [Principles of Neural Science:ISBN 0-8385-8034-3, J:49471]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Gfra1tm1Jmi/Gfra1tm2Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: B6.129-Gfra1tm1Rosl

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: B6.129-Gfra1tm1Rosl

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001087 abnormal nodose ganglion morphology "malformation of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-con/KitlSl-con
Genetic Background: either: (involves: C3H/HeJ) or (involves: C3H/HeN)

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi,Rettm14(Gfra1)Jmi/Ret+
Genetic Background: involves: 129X1/SvJ

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1(cre/ERT2)Sjn/Gfra1tm1(cre/ERT2)Sjn
Genetic Background: involves: C57BL/6

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0003585 large ureter "increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gfra1tm2Jmi/Gfra1tm3Jmi,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003604 single kidney 
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Allelic Composition: Gfra1tm2Jmi/Gfra1tm3Jmi,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra1tm1Jmi/Gfra1tm2Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfra1tm1Jmi/Gfra1tm2Jmi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm2Jmi/Gfra1tm1(cre/ERT2)Sjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0008314 abnormal pterygopalatine ganglion morphology "any structural anomaly of the small parasympathetic ganglion that supplies nerve fibers to the lacrimal, nasal, palatine and pharyngeal glands" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0008315 abnormal otic ganglion morphology "any structural anomaly of the ganglion that supplies nerve fibers to the parotid gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0009684 abnormal spinal cord lateral motor column morphology "any structural anomaly of the subclasses of motor neurons which innervate muscles in the limb; motor neurons in the lateral motor column are further organized into pools, each of which innervates a specific muscle in the limb" [PMID:8895454 "Tanabe Y, Jessell TM Diversity and pattern in the developing spinal cord. Science. 1996 Nov 15;274(5290):1115-23."]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: B6.129-Gfra1tm1Rosl

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0010981 abnormal branching involved in ureteric bud morphogenesis "anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]
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Allelic Composition: Gfra1tm2Jmi/Gfra1tm1(cre/ERT2)Sjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010983 abnormal ureteric bud invasion "any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros" [PMID:19828308]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

Allelic Composition: Gfra1tm2.1Jmi/Gfra1tm2.1Jmi
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gfra1tm3Jmi/Gfra1tm3Jmi
Genetic Background: involves: 129X1/SvJ

 MP:0011292 absent nephron "complete absence of functional filtering units in the kidney" [MGI:anna]
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Allelic Composition: Gfra1tm1Rosl/Gfra1tm1Rosl
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011760 abnormal ureteric bud tip morphology "any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [MGI:anna]
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Allelic Composition: Gfra1tm2Jmi/Gfra1tm1(cre/ERT2)Sjn
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / reaction / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / reaction / complex
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / complex / reaction






 

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