ENSMUSG00000039481


Mus musculus

Features
Gene ID: ENSMUSG00000039481
  
Biological name :Nrtn
  
Synonyms : Neurturin / Nrtn / P97463
  
Possible biological names infered from orthology : Q99748
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 56751325
Gene end: 56757530
  
Corresponding Affymetrix probe sets: 10452147 (MoGene1.0st)   1449281_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046512
NCBI entrez gene - 18188     See in Manteia.
MGI - MGI:108417
RefSeq - NM_008738
RefSeq - XM_006523801
RefSeq Peptide - NP_032764
swissprot - P97463
Ensembl - ENSMUSG00000039481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834855.1ENSDARG00000110877Danio rerio
 nrtnENSDARG00000079849Danio rerio
 NRTNENSGALG00000021647Gallus gallus
 NRTNENSG00000171119Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Artn / Q9Z0L2 / Artemin / Q5T4W7*ENSMUSG0000002853933
Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*ENSMUSG0000002214429
Pspn / persephin / O60542*ENSMUSG0000000266426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021675 nerve development IMP
 biological_processGO:0031175 neuron projection development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001037 abnormal parasympathethetic neuron morphology "malformed or absent neurons of the autonomic nervous system that are responsible for innervation of smooth muscle, cardiac muscle and glands" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gdnftm1Rosl/Gdnf+,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001348 abnormal lacrimal gland physiology 
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001993 abnormal blinking 
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gdnftm1Rosl/Gdnf+,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004990 abnormal ciliary ganglion morphology "any anomaly of the parasympathetic ganglia in the orbit behind the eye that receives preganglionic innervation through the oculomotor nerve" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gdnftm1Rosl/Gdnf+,Nrtntm1Jmi/Nrtntm1Jmi
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006162 thick eyelids "increased width of the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0006198 enophthalmos "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008313 abnormal parasympathetic postganglionic fiber "any structural anomaly of any or all of the cholinergic axonal fibers projecting from a parasympathetic ganglion to an effector organ" [MESH:A08.663.542.100.700, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008315 abnormal otic ganglion morphology "any structural anomaly of the ganglion that supplies nerve fibers to the parotid gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0012164 abnormal conjunctiva goblet cell morphology "any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it" [MGI:csmith]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0013466 keratoconjunctivitis sicca "inflammation of the cornea and conjuctiva caused by eye dryness which, in turn, is caused by either decreased tear production or increased tear film evaporation" [MGI:Anna]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0014149 abnormal lacrimal gland innervation pattern "any structural or position anomaly of the supply of nerve fibers that connect to the tubuloacinar exocrine glands that secrete the aqueous layer of the tear film (tears)" [https://en.wikipedia.org/wiki/Lacrimal_gland, MGI:Anna]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0020220 decreased tear production "decreased production of the amount of fluid produced in the eye" [GOC:NV]
Show

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / reaction / complex
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / reaction / complex






 

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