ENSMUSG00000032462


Mus musculus

Features
Gene ID: ENSMUSG00000032462
  
Biological name :Pik3cb
  
Synonyms : Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / Pik3cb / Q8BTI9
  
Possible biological names infered from orthology : P42338 / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 99036654
Gene end: 99140621
  
Corresponding Affymetrix probe sets: 10595924 (MoGene1.0st)   1453069_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035037
Ensembl peptide - ENSMUSP00000121466
Ensembl peptide - ENSMUSP00000138346
NCBI entrez gene - 74769     See in Manteia.
MGI - MGI:1922019
RefSeq - XM_011242830
RefSeq - NM_029094
RefSeq - XM_006511520
RefSeq - XM_011242829
RefSeq Peptide - NP_083370
swissprot - S4R1S1
swissprot - D3Z2Z7
swissprot - Q8BTI9
Ensembl - ENSMUSG00000032462
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3cbENSDARG00000075253Danio rerio
 PIK3CBENSGALG00000005505Gallus gallus
 P42338ENSG00000051382Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*ENSMUSG0000003993655
P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*ENSMUSG0000002766540
Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*ENSMUSG0000002057331
Pik3c2a / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSMUSG0000003066026
Pik3c2b / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSMUSG0000002644726
Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*ENSMUSG0000003362820
Pik3c2g / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 / O75747* / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma*ENSMUSG0000003022819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0001952 regulation of cell-matrix adhesion IEA
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IMP
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016310 phosphorylation ISO
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0033031 positive regulation of neutrophil apoptotic process IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0040016 embryonic cleavage IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IMP
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 cellular_componentGO:0030496 midbody IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0043560 insulin receptor substrate binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pik3catm1.1Rzl/Pik3catm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pik3cbtm1a(EUCOMM)Wtsi/Pik3cbtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Pik3cbtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz
Genetic Background: involves: 129 * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lattm8.1(CD2)Mal/Lattm8.1(CD2)Mal
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Pik3cbtm1a(EUCOMM)Wtsi/Pik3cbtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Pik3cbtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Pik3cbtm1a(EUCOMM)Wtsi/Pik3cbtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Pik3cbtm1a(EUCOMM)Wtsi/Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz
Genetic Background: involves: 129 * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz
Genetic Background: involves: 129 * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009469 skin hamartoma "a benign formation of a mass of tissue of disproportionate size and distribution in the skin, but composed of an overgrowth of mature cells and tissues that normally occur in this tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Lattm8.1(CD2)Mal/Lattm8.1(CD2)Mal
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Pik3cbtm1Bvan/Pik3cbtm1Bvan,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Siva1tm1.2Att/Siva1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: B6.129P2-Pik3cbtm1.1Ehi

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Nodaltm1.2Rob/Nodaltm3Rob
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Pik3cbtm1.1Jdo/Pik3cbtm1.1Jdo
Genetic Background: involves: C57BL/6

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tsc2tm2.2Djk/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex / reaction
 ENSMUSG00000002602 Axl / Q00993 / AXL receptor tyrosine kinase / P30530*  / complex / reaction
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / reaction / complex
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000023992 Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex
 ENSMUSG00000040751 Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028071 Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*  / complex / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000030165 Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000028698 Pik3r3 / Q64143 / Phosphatidylinositol 3-kinase regulatory subunit gamma / Q92569* / phosphoinositide-3-kinase regulatory subunit 3*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSMUSG00000030149 Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*  / complex / reaction
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / reaction / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex
 ENSMUSG00000030775 Trat1 / T cell receptor associated transmembrane adaptor 1 / Q6PIZ9*  / complex / reaction






 

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