ENSMUSG00000030775


Mus musculus

Features
Gene ID: ENSMUSG00000030775
  
Biological name :Trat1
  
Synonyms : T cell receptor associated transmembrane adaptor 1 / Trat1
  
Possible biological names infered from orthology : Q6PIZ9
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B5
Gene start: 48734690
Gene end: 48771956
  
Corresponding Affymetrix probe sets: 10439790 (MoGene1.0st)   1427532_at (Mouse Genome 430 2.0 Array)   1437561_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129808
NCBI entrez gene - 77647     See in Manteia.
MGI - MGI:1924897
RefSeq - XM_006522732
RefSeq - NM_198297
RefSeq - XM_006522730
RefSeq Peptide - NP_938039
swissprot - A0A0R4J237
Ensembl - ENSMUSG00000030775
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRAT1ENSGALG00000015362Gallus gallus
 TRAT1ENSG00000163519Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020399  T-cell receptor-associated transmembrane adapter 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001920 negative regulation of receptor recycling IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IEA
 biological_processGO:0051051 negative regulation of transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042101 T cell receptor complex IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downstream TCR signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex






 

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