ENSG00000163519


Homo sapiens

Features
Gene ID: ENSG00000163519
  
Biological name :TRAT1
  
Synonyms : Q6PIZ9 / T cell receptor associated transmembrane adaptor 1 / TRAT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q13.13
Gene start: 108822698
Gene end: 108855005
  
Corresponding Affymetrix probe sets: 217147_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410097
Ensembl peptide - ENSP00000295756
NCBI entrez gene - 50852     See in Manteia.
OMIM - 604962
RefSeq - NM_001317747
RefSeq - NM_016388
RefSeq Peptide - NP_001304676
RefSeq Peptide - NP_057472
swissprot - Q6PIZ9
swissprot - C9JF66
Ensembl - ENSG00000163519
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRAT1ENSGALG00000015362Gallus gallus
 Trat1ENSMUSG00000030775Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020399  T-cell receptor-associated transmembrane adapter 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001920 negative regulation of receptor recycling IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IDA
 biological_processGO:0051051 negative regulation of transport IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042101 T cell receptor complex IDA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Downstream TCR signaling
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex






 

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