ENSMUSG00000041417


Mus musculus

Features
Gene ID: ENSMUSG00000041417
  
Biological name :Pik3r1
  
Synonyms : P26450 / phosphoinositide-3-kinase regulatory subunit 1 / Pik3r1
  
Possible biological names infered from orthology : P27986
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 101680563
Gene end: 101768217
  
Corresponding Affymetrix probe sets: 10411782 (MoGene1.0st)   1425514_at (Mouse Genome 430 2.0 Array)   1425515_at (Mouse Genome 430 2.0 Array)   1438682_at (Mouse Genome 430 2.0 Array)   1451737_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047004
Ensembl peptide - ENSMUSP00000056774
Ensembl peptide - ENSMUSP00000140256
Ensembl peptide - ENSMUSP00000140312
NCBI entrez gene - 18708     See in Manteia.
MGI - MGI:97583
RefSeq - XM_006517570
RefSeq - NM_001024955
RefSeq - NM_001077495
RefSeq - XM_006517569
RefSeq Peptide - NP_001070963
RefSeq Peptide - NP_001020126
swissprot - P26450
swissprot - P70305
swissprot - Q80UI5
swissprot - A0A087WQM2
Ensembl - ENSMUSG00000041417
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r1ENSDARG00000038524Danio rerio
 PIK3R1ENSGALG00000014786Gallus gallus
 P27986ENSG00000145675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*ENSMUSG0000003183458
AL670603.1 / AL358075.4*ENSMUSG0000011141045
Pik3r3 / Q64143 / Phosphatidylinositol 3-kinase regulatory subunit gamma / Q92569* / phosphoinositide-3-kinase regulatory subunit 3*ENSMUSG0000002869845


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR001720  PI3K p85/p55 subunit
 IPR008936  Rho GTPase activation protein
 IPR032498  PI3K p85 subunit, inter-SH2 domain
 IPR035020  PI3K p85 subunit, C-terminal SH2 domain
 IPR035022  PI3K p85 subunit, N-terminal SH2 domain
 IPR035591  Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IDA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IGI
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IGI
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IGI
 biological_processGO:0046854 phosphatidylinositol phosphorylation ISS
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051492 regulation of stress fiber assembly IMP
 biological_processGO:0060396 growth hormone receptor signaling pathway IEA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IDA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005801 cis-Golgi network IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 cellular_componentGO:0005943 phosphatidylinositol 3-kinase complex, class IA ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:1990578 perinuclear endoplasmic reticulum membrane IDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IPI
 molecular_functionGO:0043125 ErbB-3 class receptor binding IEA
 molecular_functionGO:0043559 insulin binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IPI
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

Allelic Composition: Pik3r1tm2Dfr/Pik3r1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Pik3r1tm2Dfr/Pik3r1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1Sing/Spi1+,Spibtm1Mcs/Spibtm1Mcs
Genetic Background: involves: 129S/SvEv * 129X1/SvJ

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1m1Btlr/Pik3r1m1Btlr
Genetic Background: C57BL/6J-Pik3r1m1Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pik3r1m1Btlr/Pik3r1m1Btlr
Genetic Background: C57BL/6J-Pik3r1m1Btlr

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm2Dfr/Pik3r1+
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Pik3r1m1Btlr/Pik3r1m1Btlr
Genetic Background: C57BL/6J-Pik3r1m1Btlr

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Pik3r1m1Btlr/Pik3r1m1Btlr
Genetic Background: C57BL/6J-Pik3r1m1Btlr

Allelic Composition: Pik3r1M2Btlr/Pik3r1+
Genetic Background: C57BL/6J-Pik3r1M2Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Pik3r1M2Btlr/Pik3r1+
Genetic Background: C57BL/6J-Pik3r1M2Btlr

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Pik3r1M2Btlr/Pik3r1+
Genetic Background: C57BL/6J-Pik3r1M2Btlr

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic Background: involves: 129S6/SvEvTac

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Pik3r1M2Btlr/Pik3r1+
Genetic Background: C57BL/6J-Pik3r1M2Btlr

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic Background: involves: 129S6/SvEvTac

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic Background: involves: 129S6/SvEvTac

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic Background: involves: 129S6/SvEvTac

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Pik3r1tm1Khn/Pik3r1tm1Khn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Pik3r1m1Btlr/Pik3r1m1Btlr
Genetic Background: C57BL/6J-Pik3r1m1Btlr

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abca12tm1Lex/Abca12tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Pik3r1m1Btlr/Pik3r1m1Btlr
Genetic Background: C57BL/6J-Pik3r1m1Btlr

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm2Dfr/Pik3r1tm2Dfr
Genetic Background: either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6)

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Pik3r1tm1Tka/Pik3r1tm1Tka
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex / reaction
 ENSMUSG00000002602 Axl / Q00993 / AXL receptor tyrosine kinase / P30530*  / reaction / complex
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex / reaction
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / reaction / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000023992 Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*  / reaction / complex
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / reaction / complex
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex
 ENSMUSG00000040751 Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*  / reaction / complex
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028071 Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000030165 Klrd1 / O54707 / Natural killer cells antigen CD94 / Q13241* / killer cell lectin like receptor D1*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000030149 Klrk1 / O54709 / NKG2-D type II integral membrane protein / P26718* / killer cell lectin like receptor K1*  / reaction / complex
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / complex / reaction
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction / complex
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction / complex
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / complex / reaction
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000033220 Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*  / reaction / complex
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / complex / reaction
 ENSMUSG00000042817 Flt3 / fms related tyrosine kinase 3 / P36888*  / complex
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction / complex
 ENSMUSG00000026009 Icos / Q9WVS0 / Inducible T-cell costimulator / Q9Y6W8*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / complex / reaction
 ENSMUSG00000110206 Flt3l / P49772 / Fms-related tyrosine kinase 3 ligand / FLT3LG* / P49771*  / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSMUSG00000073982 Rhog / P84096 / ras homolog family member G / P84095*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / reaction / complex
 ENSMUSG00000025017 Q9EQ32 / Pik3ap1 / phosphoinositide-3-kinase adaptor protein 1 / Q6ZUJ8*  / complex
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000030724 Cd19 / P25918 / Mus musculus CD19 antigen (Cd19), transcript variant 2, mRNA. / P15391* / CD19 molecule*  / complex
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / reaction / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / reaction / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex
 ENSMUSG00000047953 Gp5 / glycoprotein V platelet / P40197*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex
 ENSMUSG00000030775 Trat1 / T cell receptor associated transmembrane adaptor 1 / Q6PIZ9*  / complex / reaction






 

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