ENSMUSG00000004508


Mus musculus

Features
Gene ID: ENSMUSG00000004508
  
Biological name :Gab2
  
Synonyms : Gab2
  
Possible biological names infered from orthology : GAB4 / GRB2 associated binding protein 2 / GRB2 associated binding protein family member 4 / Q2WGN9 / Q9UQC2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 97081586
Gene end: 97308946
  
Corresponding Affymetrix probe sets: 10555027 (MoGene1.0st)   1419829_a_at (Mouse Genome 430 2.0 Array)   1420785_at (Mouse Genome 430 2.0 Array)   1439786_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004622
Ensembl peptide - ENSMUSP00000146200
NCBI entrez gene - 14389     See in Manteia.
MGI - MGI:1333854
RefSeq - NM_010248
RefSeq - NM_001162477
RefSeq Peptide - NP_001155949
RefSeq Peptide - NP_034378
swissprot - Q3ZB57
swissprot - Q3ZB59
Ensembl - ENSMUSG00000004508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gab2ENSDARG00000105120Danio rerio
 GAB2ENSG00000033327Homo sapiens
 GAB4ENSG00000215568Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*ENSMUSG0000003171438
Gab3 / Q8BSM5 / GRB2-associated-binding protein 3 / Q8WWW8*ENSMUSG0000003275029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Signaling by SCF-KIT
Role of LAT2/NTAL/LAB on calcium mobilization
RET signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gab2tm3.1Thir/Gab2tm3.1Thir
Genetic Background: involves: 129T/SvJcl * C57BL/6Jcl

Allelic Composition: Gab2tm4.1Thir/Gab2tm4.1Thir
Genetic Background: involves: 129T/SvJcl * C57BL/6Jcl

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ercc8tm1Jhjh/Ercc8tm1Jhjh,Xpctm1Ecf/Xpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gab2tm3.1Thir/Gab2tm3.1Thir
Genetic Background: involves: 129T/SvJcl * C57BL/6Jcl

Allelic Composition: Gab2tm4.1Thir/Gab2tm4.1Thir
Genetic Background: involves: 129T/SvJcl * C57BL/6Jcl

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gab2tm3.1Thir/Gab2tm3.1Thir
Genetic Background: involves: 129T/SvJcl * C57BL/6Jcl

Allelic Composition: Gab2tm4.1Thir/Gab2tm4.1Thir
Genetic Background: involves: 129T/SvJcl * C57BL/6Jcl

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010961 increased compact bone mass 
Show

Allelic Composition: Grap2tm1Amch/Grap2tm1Amch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000040751 Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*  / complex
 ENSMUSG00000110206 Flt3l / P49772 / Fms-related tyrosine kinase 3 ligand / FLT3LG* / P49771*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000042817 Flt3 / fms related tyrosine kinase 3 / P36888*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex






 

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