Manteia - Molecule gene

ENSMUSG00000068758

Mus musculus

Features

Gene ID:	ENSMUSG00000068758

Biological name :	Il3ra

Synonyms :	Il3ra / Interleukin-3 receptor subunit alpha / P26952

Possible biological names infered from orthology :	P26951

Species:	Mus musculus

Chr. number:	14
Strand:	1
Band:	A1
Gene start:	14346275
Gene end:	14356011

Corresponding Affymetrix probe sets:	10412760 (MoGene1.0st) 1419712_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000088079 Ensembl peptide - ENSMUSP00000153358 Ensembl peptide - ENSMUSP00000153460 Ensembl peptide - ENSMUSP00000153664 Ensembl peptide - ENSMUSP00000153086 NCBI entrez gene - 16188 See in Manteia. MGI - MGI:96553 RefSeq - XM_017315868 RefSeq - XM_017315864 RefSeq - XM_017315865 RefSeq - XM_017315866 RefSeq - XM_017315867 RefSeq - NM_008369 RefSeq - XM_006517935 RefSeq - XM_006517940 RefSeq - XM_006517941 RefSeq - XM_006517942 RefSeq - XM_006517946 RefSeq - XM_006517947 RefSeq - XM_011244734 RefSeq - XM_017315860 RefSeq - XM_017315861 RefSeq - XM_017315862 RefSeq - XM_017315863 RefSeq Peptide - NP_032395 swissprot - A0A286YE23 swissprot - A0A286YE20 swissprot - P26952 Ensembl - ENSMUSG00000068758

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000046156	Gallus gallus
	ENSGALG00000019147	Gallus gallus
CSF2RA	ENSGALG00000016693	Gallus gallus
IL3RA	ENSG00000185291	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*	ENSMUSG00000059326	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR003532	Short hematopoietin receptor, family 2, conserved site
IPR013783	Immunoglobulin-like fold
IPR015321	Type I cytokine receptor, cytokine-binding domain
IPR036116	Fibronectin type III superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001558	regulation of cell growth	IGI
biological_process	GO:0019221	cytokine-mediated signaling pathway	IEA
biological_process	GO:0030224	monocyte differentiation	IGI
biological_process	GO:0036016	cellular response to interleukin-3	IEA
biological_process	GO:0038156	interleukin-3-mediated signaling pathway	IDA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0012505	endomembrane system	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004896	cytokine receptor activity	IEA
molecular_function	GO:0004912	interleukin-3 receptor activity	IDA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0019978	interleukin-3 binding	IPI

Pathways (from Reactome)

Pathway description

Interleukin-3, Interleukin-5 and GM-CSF signaling

RAF/MAP kinase cascade

Interleukin receptor SHC signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005460	abnormal leukopoiesis	"anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rp1^tm1Jnz/Rp1^tm1Eap Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rp1^tm1Jnz/Rp1^tm1Eap Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: C58/J Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: AKR/J Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: RF/J Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: NZB/BlNJ Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: A/WySnJ Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: A/HeJ Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: BUB/BnJ Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: SM/J Allelic Composition: Il3ra^m1/Il3ra^m1 Genetic Background: CE/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000005469	P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*	/ reaction
ENSMUSG00000020919	P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*	/ complex / reaction
ENSMUSG00000004043	P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*	/ complex / reaction
ENSMUSG00000059923	Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*	/ reaction / complex
ENSMUSG00000024789	Jak2 / Janus kinase 2 / O60674*	/ reaction / complex
ENSMUSG00000027665	P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*	/ complex / reaction
ENSMUSG00000042626	Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*	/ complex / reaction
ENSMUSG00000032462	Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*	/ complex / reaction
ENSMUSG00000041417	P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*	/ complex / reaction
ENSMUSG00000039936	O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*	/ complex / reaction
ENSMUSG00000043733	P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ complex / reaction
ENSMUSG00000004508	Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*	/ complex
ENSMUSG00000024241	Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*	/ reaction / complex
ENSMUSG00000026288	Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*	/ reaction / complex
ENSMUSG00000068758	Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*	/ complex
ENSMUSG00000004266	Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*	/ reaction / complex
ENSMUSG00000071714	P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*	/ complex
ENSMUSG00000071713	Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...	/ complex
ENSMUSG00000032737	Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr