ENSMUSG00000071713


Mus musculus

Features
Gene ID: ENSMUSG00000071713
  
Biological name :Csf2rb
  
Synonyms : Csf2rb / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P26955
  
Possible biological names infered from orthology : colony stimulating factor 2 receptor beta common subunit / P32927
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 78325798
Gene end: 78353847
  
Corresponding Affymetrix probe sets: 10425066 (MoGene1.0st)   1421326_at (Mouse Genome 430 2.0 Array)   1450200_s_at (Mouse Genome 430 2.0 Array)   1455660_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155050
Ensembl peptide - ENSMUSP00000154836
Ensembl peptide - ENSMUSP00000155092
Ensembl peptide - ENSMUSP00000155406
Ensembl peptide - ENSMUSP00000094082
NCBI entrez gene - 12983     See in Manteia.
MGI - MGI:1339759
RefSeq - XM_006520390
RefSeq - NM_001358854
RefSeq - NM_007780
RefSeq - XM_006520387
RefSeq - XM_006520388
RefSeq Peptide - NP_001345783
RefSeq Peptide - NP_031806
swissprot - P26955
Ensembl - ENSMUSG00000071713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csf2rbENSDARG00000076586Danio rerio
 ENSGALG00000025881Gallus gallus
 CSF2RBENSG00000100368Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*ENSMUSG0000007171489


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR011365  Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IGI
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Surfactant metabolism
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Csf2rbtm1Cgb/Csf2rbtm1Cgb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Csf2rbtm1Cgb/Csf2rbtm1Cgb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Csf2rbtm1Mur/Csf2rbtm1Mur,Il3tm1Tyb/Il3tm1Tyb
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Csf2rbtm1Cgb/Csf2rbtm1Cgb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+,Tg(Vil-cre)20Syr/0,TgTn(sb-T2/Onc)76Dla/0
Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

 MP:0010998 pulmonary alveolar proteinosis "abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf2rbtm1Cgb/Csf2rbtm1Cgb
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex / reaction
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / complex / reaction
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / reaction / complex






 

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