ENSMUSG00000005364


Mus musculus

Features
Gene ID: ENSMUSG00000005364
  
Biological name :Il5ra
  
Synonyms : Il5ra / Interleukin-5 receptor subunit alpha / P21183
  
Possible biological names infered from orthology : Q01344
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: E1
Gene start: 106710357
Gene end: 106749037
  
Corresponding Affymetrix probe sets: 10546762 (MoGene1.0st)   1421620_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144825
Ensembl peptide - ENSMUSP00000129781
Ensembl peptide - ENSMUSP00000144718
NCBI entrez gene - 16192     See in Manteia.
MGI - MGI:96558
RefSeq - NM_008370
RefSeq - XM_017321406
RefSeq Peptide - NP_032396
swissprot - A0A0N4SUU4
swissprot - P21183
swissprot - Q05A81
Ensembl - ENSMUSG00000005364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il13ra2ENSDARG00000039436Danio rerio
 IL5RAENSGALG00000008267Gallus gallus
 IL5RAENSG00000091181Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*ENSMUSG0000001705721
O88786 / Il13ra2 / Interleukin-13 receptor subunit alpha-2 / Q14627*ENSMUSG0000003128920


Protein motifs (from Interpro)
Interpro ID Name
 IPR003532  Short hematopoietin receptor, family 2, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032674 regulation of interleukin-5 production IMP
 biological_processGO:0071310 cellular response to organic substance IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Il5tm1Ktk/Il5+
Genetic Background: B6.129S4-Il5tm1Ktk

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002360 abnormal spleen B cell corona morphology "anomalous structure of the area of the splenic white pulp dominated by B lymphocyte follicles " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002602 abnormal eosinophil count "deviation from the normal numbers of eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004940 abnormal B-1 B cell morphology "any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk
Genetic Background: B6.129P2-Il5ratm1Ktk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction






 

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