ENSMUSG00000026288


Mus musculus

Features
Gene ID: ENSMUSG00000026288
  
Biological name :Inpp5d
  
Synonyms : Inpp5d / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q9ES52
  
Possible biological names infered from orthology : inositol polyphosphate-5-phosphatase D / Q92835
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 87620312
Gene end: 87720507
  
Corresponding Affymetrix probe sets: 10348244 (MoGene1.0st)   1418110_a_at (Mouse Genome 430 2.0 Array)   1424195_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131244
Ensembl peptide - ENSMUSP00000132384
Ensembl peptide - ENSMUSP00000044647
Ensembl peptide - ENSMUSP00000072763
Ensembl peptide - ENSMUSP00000126569
Ensembl peptide - ENSMUSP00000127941
Ensembl peptide - ENSMUSP00000128700
Ensembl peptide - ENSMUSP00000130336
NCBI entrez gene - 16331     See in Manteia.
MGI - MGI:107357
RefSeq - NM_001110192
RefSeq - XM_006529150
RefSeq - XM_006529149
RefSeq - NM_001110193
RefSeq - NM_010566
RefSeq - XM_006529152
RefSeq - XM_006529151
RefSeq Peptide - NP_001103663
RefSeq Peptide - NP_001103662
RefSeq Peptide - NP_034696
swissprot - Q9ES52
swissprot - F7BZA7
swissprot - E9Q752
Ensembl - ENSMUSG00000026288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5dENSDARG00000074283Danio rerio
 INPP5DENSGALG00000035498Gallus gallus
 INPP5DENSG00000168918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273740
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297317
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380517
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889413
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117313
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457012
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG0000002692511
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG000000061278


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000980  SH2 domain
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0009968 negative regulation of signal transduction IMP
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IMP
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0045621 positive regulation of lymphocyte differentiation IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045656 negative regulation of monocyte differentiation IMP
 biological_processGO:0045659 negative regulation of neutrophil differentiation IMP
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0050777 negative regulation of immune response IMP
 biological_processGO:0050869 negative regulation of B cell activation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0034594 phosphatidylinositol trisphosphate phosphatase activity IDA
 molecular_functionGO:0051425 PTB domain binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Downstream TCR signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm1.1Asor/Slc6a3tm1.1Asor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Leprm1Anu/Leprm1Anu
Genetic Background: C57BL/6JAnu-Leprm1Anu

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm1.1Asor/Slc6a3tm1.1Asor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Leprm1Anu/Leprm1Anu
Genetic Background: C57BL/6JAnu-Leprm1Anu

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprm1Anu/Leprm1Anu
Genetic Background: C57BL/6JAnu-Leprm1Anu

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a3tm1.1Asor/Slc6a3tm1.1Asor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1.1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002445 abnormal mononuclear leukocyte morphology/development "anomalous structure, differentiation, or number of either of the mature lymphocytes or monocytes found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003795 abnormal bone structure 
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Inpp5dm2Btlr/Inpp5dm2Btlr
Genetic Background: C57BL/6J-Inpp5dm2Btlr

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0005068 abnormal NK cell morphology/development "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5dm1Btlr/Inpp5dm1Btlr
Genetic Background: C57BL/6J-Inpp5dm1Btlr

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Muc2m3Btlr/Muc2m3Btlr
Genetic Background: C57BL/6J-Muc2m3Btlr

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129 * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Inpp5dtm1Wgk/Inpp5dtm1.1Wgk,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: B6.129P2/OlaHsd-Inpp5dtm1Dmt

Allelic Composition: Inpp5del20/Inpp5del20
Genetic Background: B6.129-Inpp5del20

Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Lrp6Cd/Lrp6+
Genetic Background: involves: A * 129/Sv

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009317 follicular lymphoma "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009318 splenic marginal zone lymphoma "neoplasm arising from the B cell-rich zones of the spleen" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh,Rag1tm1(GFP)Imku/Rag1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic Background: involves: 129P2/OlaHsd

 MP:0010286 increased plasmacytoma incidence "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5dtm1Rkh/Inpp5dtm1Rkh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / reaction / complex
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / reaction / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex / reaction






 

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