ENSMUSG00000006127


Mus musculus

Features
Gene ID: ENSMUSG00000006127
  
Biological name :Inpp5k
  
Synonyms : inositol polyphosphate 5-phosphatase K / Inpp5k / Q8C5L6
  
Possible biological names infered from orthology : Q9BT40
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75630988
Gene end: 75648871
  
Corresponding Affymetrix probe sets: 10378681 (MoGene1.0st)   1416195_at (Mouse Genome 430 2.0 Array)   1438446_x_at (Mouse Genome 430 2.0 Array)   1456412_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006286
Ensembl peptide - ENSMUSP00000119996
Ensembl peptide - ENSMUSP00000121060
NCBI entrez gene - 19062     See in Manteia.
MGI - MGI:1194899
RefSeq - XM_006532507
RefSeq - NM_008916
RefSeq Peptide - NP_032942
swissprot - Q5ND43
swissprot - Q5ND44
swissprot - Q8C5L6
swissprot - D6RI67
Ensembl - ENSMUSG00000006127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5kaENSDARG00000099563Danio rerio
 inpp5kbENSDARG00000078618Danio rerio
 INPP5KENSGALG00000002739Gallus gallus
 INPP5KENSG00000132376Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457046
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117326
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889425
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297324
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380523
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273722
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628821
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG0000002692518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0005979 regulation of glycogen biosynthetic process IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0010829 negative regulation of glucose transmembrane transport ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032870 cellular response to hormone stimulus IDA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035305 negative regulation of dephosphorylation IMP
 biological_processGO:0035810 positive regulation of urine volume IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0045719 negative regulation of glycogen biosynthetic process IMP
 biological_processGO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation IEA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation ISO
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0051926 negative regulation of calcium ion transport ISS
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0090315 negative regulation of protein targeting to membrane IEA
 biological_processGO:0097178 ruffle assembly IEA
 biological_processGO:2000466 negative regulation of glycogen (starch) synthase activity IMP
 biological_processGO:2001153 positive regulation of renal water transport IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity IEA
 molecular_functionGO:0005000 vasopressin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016312 inositol bisphosphate phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
 molecular_functionGO:0034594 phosphatidylinositol trisphosphate phosphatase activity ISS
 molecular_functionGO:0034595 phosphatidylinositol phosphate 5-phosphatase activity ISO
 molecular_functionGO:0046030 inositol trisphosphate phosphatase activity ISO
 molecular_functionGO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
 molecular_functionGO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxd11tm1Mrc/Hoxd11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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