ENSMUSG00000028894


Mus musculus

Features
Gene ID: ENSMUSG00000028894
  
Biological name :Inpp5b
  
Synonyms : Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase
  
Possible biological names infered from orthology : inositol polyphosphate-5-phosphatase B / P32019
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 124741850
Gene end: 124801511
  
Corresponding Affymetrix probe sets: 10507933 (MoGene1.0st)   1451330_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139221
Ensembl peptide - ENSMUSP00000092375
Ensembl peptide - ENSMUSP00000115176
Ensembl peptide - ENSMUSP00000122568
NCBI entrez gene - 16330     See in Manteia.
MGI - MGI:103257
RefSeq - XM_006502804
RefSeq - XM_006502805
RefSeq - XM_011240450
RefSeq - NM_008385
RefSeq Peptide - NP_032411
swissprot - Q8K337
swissprot - A0A0A0MQG5
swissprot - F2Z437
Ensembl - ENSMUSG00000028894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5bENSDARG00000103683Danio rerio
 INPP5BENSGALG00000001606Gallus gallus
 INPP5BENSG00000204084Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117341
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297323
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380521
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628816
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457016
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273715
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG0000002692512
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG0000000612712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR008936  Rho GTPase activation protein
 IPR013783  Immunoglobulin-like fold
 IPR031896  INPP5B, PH domain
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation ISO
 biological_processGO:0070613 regulation of protein processing IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity ISO
 molecular_functionGO:0052745 inositol phosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm
Genetic Background: 129/Sv-Inpp5btm1Nbm

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Ocrltm1Nbm,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Ocrltm1Nbm,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/Tg(INPP5B)CNbm
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm
Genetic Background: 129/Sv-Inpp5btm1Nbm

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm
Genetic Background: 129/Sv-Inpp5btm1Nbm

Allelic Composition: Inpp5btm2.1Nbm/Inpp5btm2.1Nbm
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm
Genetic Background: 129/Sv-Inpp5btm1Nbm

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm
Genetic Background: 129/Sv-Inpp5btm1Nbm

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm
Genetic Background: 129/Sv-Inpp5btm1Nbm

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0011555 increased urine microglobulin level "greater than the normal amount of any globulin (or any fragment of a globulin) of low molecular weight in the urine" [MGI:anna]
Show

Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Inpp5btm1Nbm/Inpp5btm1Nbm,Ocrltm1Nbm/Y,Tg(INPP5B)CNbm/0
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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