ENSMUSG00000026925


Mus musculus

Features
Gene ID: ENSMUSG00000026925
  
Biological name :Inpp5e
  
Synonyms : 72 kDa inositol polyphosphate 5-phosphatase / Inpp5e / Q9JII1
  
Possible biological names infered from orthology : inositol polyphosphate-5-phosphatase E / Q9NRR6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 26396249
Gene end: 26409203
  
Corresponding Affymetrix probe sets: 10481011 (MoGene1.0st)   1423229_at (Mouse Genome 430 2.0 Array)   1423230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109724
Ensembl peptide - ENSMUSP00000118739
Ensembl peptide - ENSMUSP00000119485
Ensembl peptide - ENSMUSP00000123272
NCBI entrez gene - 64436     See in Manteia.
MGI - MGI:1927753
RefSeq - NM_001290437
RefSeq - NM_033134
RefSeq Peptide - NP_001277366
RefSeq Peptide - NP_149125
swissprot - Q9JII1
swissprot - A2AIX0
swissprot - F6X9A4
swissprot - F6XC48
Ensembl - ENSMUSG00000026925
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5eENSDARG00000103926Danio rerio
 INPP5EENSGALG00000001964Gallus gallus
 INPP5EENSG00000148384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297322
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380521
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273720
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628820
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117319
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889419
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457017
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG0000000612713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IDA
 biological_processGO:0046855 inositol phosphate dephosphorylation IDA
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane
ARL13B-mediated ciliary trafficking of INPP5E


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

Allelic Composition: Inpp5etm1.1Ssch/Inpp5etm1.2Ssch,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

Allelic Composition: Inpp5em1Tc/Inpp5em1Tc
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

Allelic Composition: Inpp5em1Tc/Inpp5em1Tc
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Inpp5em1Tc/Inpp5em1Tc
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdm6atm1.2Kaig/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Inpp5em1Tc/Inpp5em1Tc
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5etm1.1Ssch/Inpp5etm1.2Ssch,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Th/t13
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026239 Pde6d / O55057 / Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta / O43924* / phosphodiesterase 6D*  / complex / reaction
 ENSMUSG00000022911 Arl13b / Q640N2 / ADP-ribosylation factor-like protein 13B / Q3SXY8* / ADP ribosylation factor like GTPase 13B*  / reaction / complex






 

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