ENSMUSG00000026239


Mus musculus

Features
Gene ID: ENSMUSG00000026239
  
Biological name :Pde6d
  
Synonyms : O55057 / Pde6d / Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta
  
Possible biological names infered from orthology : O43924 / phosphodiesterase 6D
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 86542994
Gene end: 86582629
  
Corresponding Affymetrix probe sets: 10356339 (MoGene1.0st)   1416843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027444
Ensembl peptide - ENSMUSP00000137820
Ensembl peptide - ENSMUSP00000137956
NCBI entrez gene - 18582     See in Manteia.
MGI - MGI:1270843
RefSeq - NM_008801
RefSeq - XM_011247941
RefSeq Peptide - NP_032827
swissprot - M0QWR1
swissprot - O55057
swissprot - Q3TDQ8
swissprot - M0QWG6
Ensembl - ENSMUSG00000026239
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde6dENSDARG00000074892Danio rerio
 PDE6DENSGALG00000033062Gallus gallus
 PDE6DENSG00000156973Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008015  GMP phosphodiesterase, delta subunit
 IPR014756  Immunoglobulin E-set
 IPR017287  Retinal rod rhodopsin-sensitive cGMP 3", 5"-cyclic phosphodiesterase, delta subunit
 IPR037036  GMP phosphodiesterase, delta subunit superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007602 phototransduction TAS
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0005095 GTPase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity TAS


Pathways (from Reactome)
Pathway description
ARL13B-mediated ciliary trafficking of INPP5E


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022911 Arl13b / Q640N2 / ADP-ribosylation factor-like protein 13B / Q3SXY8* / ADP ribosylation factor like GTPase 13B*  / reaction / complex
 ENSMUSG00000026925 Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*  / complex / reaction






 

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