ENSMUSG00000022911


Mus musculus

Features
Gene ID: ENSMUSG00000022911
  
Biological name :Arl13b
  
Synonyms : ADP-ribosylation factor-like protein 13B / Arl13b / Q640N2
  
Possible biological names infered from orthology : ADP ribosylation factor like GTPase 13B / Q3SXY8
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C1.3
Gene start: 62793685
Gene end: 62847040
  
Corresponding Affymetrix probe sets: 10440246 (MoGene1.0st)   1430322_at (Mouse Genome 430 2.0 Array)   1437021_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086703
NCBI entrez gene - 68146     See in Manteia.
MGI - MGI:1915396
RefSeq - XM_006522505
RefSeq - NM_026577
RefSeq - XM_006522503
RefSeq - XM_006522504
RefSeq Peptide - NP_080853
swissprot - Q640N2
Ensembl - ENSMUSG00000022911
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl13bENSDARG00000012763Danio rerio
 ARL13BENSGALG00000015412Gallus gallus
 ARL13BENSG00000169379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arl13a / Q9D416 / ADP-ribosylation factor-like protein 13A / Q5H913* / ADP ribosylation factor like GTPase 13A*ENSMUSG0000005254923
Arfrp1 / Q8BXL7 / ADP-ribosylation factor-related protein 1 / Q13795*ENSMUSG0000003867114


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0021532 neural tube patterning IMP
 biological_processGO:0021830 interneuron migration from the subpallium to the cortex IMP
 biological_processGO:0021943 formation of radial glial scaffolds IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0070986 left/right axis specification IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
ARL13B-mediated ciliary trafficking of INPP5E


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
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Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0020384 absent kidney epithelial cell primary cilium "absence of non-motile cilia on cells of the renal tubule or collecting duct" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Inpp5aGt(OST50073)Lex/Inpp5a+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026239 Pde6d / O55057 / Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta / O43924* / phosphodiesterase 6D*  / complex / reaction
 ENSMUSG00000026925 Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*  / complex / reaction






 

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