ENSMUSG00000034570


Mus musculus

Features
Gene ID: ENSMUSG00000034570
  
Biological name :Inpp5j
  
Synonyms : Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
  
Possible biological names infered from orthology : inositol polyphosphate-5-phosphatase J / Q15735
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 3494375
Gene end: 3504821
  
Corresponding Affymetrix probe sets: 10383717 (MoGene1.0st)   1433941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105646
Ensembl peptide - ENSMUSP00000139302
Ensembl peptide - ENSMUSP00000139214
Ensembl peptide - ENSMUSP00000139000
Ensembl peptide - ENSMUSP00000046625
Ensembl peptide - ENSMUSP00000105645
NCBI entrez gene - 170835     See in Manteia.
MGI - MGI:2158663
RefSeq - NM_172439
RefSeq - XM_006514554
RefSeq - XM_017314305
RefSeq - XM_017314306
RefSeq Peptide - NP_766027
swissprot - P59644
swissprot - D3Z3P9
swissprot - A0A075B6D7
swissprot - D3Z3Q0
swissprot - V9GX61
swissprot - V9GXL7
Ensembl - ENSMUSG00000034570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp5jaENSDARG00000078542Danio rerio
 inpp5jbENSDARG00000093359Danio rerio
 INPP5JENSGALG00000023266Gallus gallus
 INPP5JENSG00000185133Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG0000000612721
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297321
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380519
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117317
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889416
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628814
Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*ENSMUSG0000003273712
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG0000002692511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane ISO
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043198 dendritic shaft IDA
 molecular_functionGO:0004445 inositol-polyphosphate 5-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
 molecular_functionGO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
 molecular_functionGO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
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Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
Show

Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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