ENSMUSG00000032737


Mus musculus

Features
Gene ID: ENSMUSG00000032737
  
Biological name :Inppl1
  
Synonyms : Inppl1 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / Q6P549
  
Possible biological names infered from orthology : inositol polyphosphate phosphatase like 1 / O15357
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 101822632
Gene end: 101838229
  
Corresponding Affymetrix probe sets: 10565996 (MoGene1.0st)   1460394_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139910
Ensembl peptide - ENSMUSP00000148066
Ensembl peptide - ENSMUSP00000147394
Ensembl peptide - ENSMUSP00000048057
Ensembl peptide - ENSMUSP00000132883
NCBI entrez gene - 16332     See in Manteia.
MGI - MGI:1333787
RefSeq - XM_006507392
RefSeq - XM_006507391
RefSeq - XM_011241682
RefSeq - NM_001122739
RefSeq - NM_010567
RefSeq - XM_017321991
RefSeq Peptide - NP_034697
RefSeq Peptide - NP_001116211
swissprot - Q6P549
swissprot - A0A1B0GST7
swissprot - A0A087WPT7
swissprot - A0A1B0GR64
Ensembl - ENSMUSG00000032737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inppl1aENSDARG00000104222Danio rerio
 INPPL1ENSGALG00000004336Gallus gallus
 INPPL1ENSG00000165458Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*ENSMUSG0000002628838
Synj2 / Q9D2G5 / Synaptojanin-2 / O15056*ENSMUSG0000002380515
Synj1 / synaptojanin 1 / O43426*ENSMUSG0000002297315
Ocrl / Q6NVF0 / Inositol polyphosphate 5-phosphatase OCRL-1 / Q01968* / OCRL, inositol polyphosphate-5-phosphatase*ENSMUSG0000000117312
Inpp5b / Q8K337 / Type II inositol 1,4,5-trisphosphate 5-phosphatase / P32019* / inositol polyphosphate-5-phosphatase B*ENSMUSG0000002889412
Inpp5j / P59644 / Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A / Q15735* / inositol polyphosphate-5-phosphatase J*ENSMUSG0000003457010
Inpp5e / Q9JII1 / 72 kDa inositol polyphosphate 5-phosphatase / Q9NRR6* / inositol polyphosphate-5-phosphatase E*ENSMUSG0000002692510
Inpp5k / Q8C5L6 / inositol polyphosphate 5-phosphatase K / Q9BT40*ENSMUSG000000061278


Protein motifs (from Interpro)
Interpro ID Name
 IPR000300  Inositol polyphosphate-related phosphatase
 IPR000980  SH2 domain
 IPR001660  Sterile alpha motif domain
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IMP
 biological_processGO:0006897 endocytosis ISO
 biological_processGO:0007015 actin filament organization ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0044255 cellular lipid metabolic process IMP
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IEA
 biological_processGO:0097178 ruffle assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0042169 SH2 domain binding ISO


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Inppl1tm1Glas/Inppl1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Frat1tm1Brn/Frat1tm1Brn,Frat2tm2Brn/Frat2tm2Brn,Peg12tm1Brn/Peg12tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / complex / reaction
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / reaction / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / reaction / complex
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex






 

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