ENSMUSG00000036117


Mus musculus

Features
Gene ID: ENSMUSG00000036117
  
Biological name :Il5
  
Synonyms : Il5 / Interleukin-5 / P04401
  
Possible biological names infered from orthology : P05113
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 53720794
Gene end: 53725106
  
Corresponding Affymetrix probe sets: 10376054 (MoGene1.0st)   1450550_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043369
NCBI entrez gene - 16191     See in Manteia.
MGI - MGI:96557
RefSeq - NM_010558
RefSeq Peptide - NP_034688
swissprot - P04401
swissprot - Q5SV01
Ensembl - ENSMUSG00000036117
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL5ENSG00000113525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000186  Interleukin-5
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0045645 positive regulation of eosinophil differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005137 interleukin-5 receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Klhl1as+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0001272 increased metastatic potential 
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Allelic Composition: Tnfrsf21tm2Gne/Tnfrsf21tm2Gne,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001376 abnormal mating receptivity "deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior" [J:51468]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbn1tm3.1Hcd/Fbn1tm3.1Hcd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Klhl1/Atxn8ostm1.1Mdk/Klhl1/Klhl1as+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm3Anjm/Il5tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm3Anjm/Il5tm3Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm,Il5tm3Anjm/Il5tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0004940 abnormal B-1 B cell morphology "any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Tnfrsf21tm2Gne/Tnfrsf21tm2Gne,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13tm1Anjm,Il5tm3Anjm/Il5tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008627 decreased circulating interleukin-5 level "reduction in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Fbn1tm3.1Hcd/Fbn1tm3.1Hcd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Tnfrsf21tm2Gne/Tnfrsf21tm2Gne,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Il5tm1Ktk/Il5+
Genetic Background: B6.129S4-Il5tm1Ktk

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000032737 Inppl1 / Q6P549 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 / O15357* / inositol polyphosphate phosphatase like 1*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000026288 Inpp5d / Q9ES52 / Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 / Q92835* / inositol polyphosphate-5-phosphatase D*  / reaction / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex






 

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