ENSMUSG00000039936


Mus musculus

Features
Gene ID: ENSMUSG00000039936
  
Biological name :Pik3cd
  
Synonyms : O35904 / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / Pik3cd
  
Possible biological names infered from orthology : O00329
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 149649168
Gene end: 149702571
  
Corresponding Affymetrix probe sets: 10518686 (MoGene1.0st)   1422991_at (Mouse Genome 430 2.0 Array)   1422992_s_at (Mouse Genome 430 2.0 Array)   1443798_at (Mouse Genome 430 2.0 Array)   1446770_at (Mouse Genome 430 2.0 Array)   1453281_at (Mouse Genome 430 2.0 Array)   1458321_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115542
Ensembl peptide - ENSMUSP00000113844
Ensembl peptide - ENSMUSP00000115716
Ensembl peptide - ENSMUSP00000136045
Ensembl peptide - ENSMUSP00000121843
Ensembl peptide - ENSMUSP00000119858
Ensembl peptide - ENSMUSP00000118988
Ensembl peptide - ENSMUSP00000036434
Ensembl peptide - ENSMUSP00000101313
Ensembl peptide - ENSMUSP00000101314
Ensembl peptide - ENSMUSP00000101315
Ensembl peptide - ENSMUSP00000112863
NCBI entrez gene - 18707     See in Manteia.
MGI - MGI:1098211
RefSeq - XM_017320038
RefSeq - NM_001164051
RefSeq - NM_001164052
RefSeq - NM_008840
RefSeq - XM_006538641
RefSeq - XM_006538642
RefSeq - XM_006538643
RefSeq - XM_006538644
RefSeq - XM_006538645
RefSeq - XM_006538646
RefSeq - XM_006538647
RefSeq - XM_006538648
RefSeq - XM_006538649
RefSeq - XM_006538650
RefSeq - XM_006538651
RefSeq - XM_006538652
RefSeq - XM_006538653
RefSeq - XM_017320037
RefSeq - NM_001029837
RefSeq - NM_001164049
RefSeq - NM_001164050
RefSeq Peptide - NP_001025008
RefSeq Peptide - NP_001157521
RefSeq Peptide - NP_001157522
RefSeq Peptide - NP_001157523
RefSeq Peptide - NP_001157524
RefSeq Peptide - NP_032866
swissprot - Q3T9Y0
swissprot - Q3TBW3
swissprot - B1AS28
swissprot - Q8CI98
swissprot - B0QZL5
swissprot - Q3UDT3
swissprot - B1AS27
swissprot - B1AS26
swissprot - B1AS25
swissprot - B1AS24
swissprot - O35904
Ensembl - ENSMUSG00000039936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3cdENSDARG00000003250Danio rerio
 PIK3CDENSGALG00000002583Gallus gallus
 O00329ENSG00000171608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*ENSMUSG0000003246256
P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*ENSMUSG0000002766541
Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*ENSMUSG0000002057331
Pik3c2a / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSMUSG0000003066027
Pik3c2b / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSMUSG0000002644726
Pik3c2g / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 / O75747* / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma*ENSMUSG0000003022820
Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*ENSMUSG0000003362819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030168 platelet activation IBA
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0033031 positive regulation of neutrophil apoptotic process ISO
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042113 B cell activation IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Pik3cdm1Btlr/Pik3cdm1Btlr
Genetic Background: C57BL/6J-Pik3cdm1Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scnn1btm1.1Ipt/Scnn1b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Scnn1btm1.1Ipt/Scnn1b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0008202 absent B-1 B cells "absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Scnn1btm1.1Ipt/Scnn1b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
Genetic Background: B6.129P2-Pik3cdtm1.1Bvan

 MP:0010187 decreased T follicular helper cell number "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

Allelic Composition: Pik3cdm2Btlr/Pik3cd+
Genetic Background: C57BL/6J-Pik3cdm2Btlr

 MP:0020002 increased response to antigen "increased immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Pik3cdm2Btlr/Pik3cdm2Btlr
Genetic Background: C57BL/6J-Pik3cdm2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / reaction / complex
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000025017 Q9EQ32 / Pik3ap1 / phosphoinositide-3-kinase adaptor protein 1 / Q6ZUJ8*  / complex
 ENSMUSG00000028698 Pik3r3 / Q64143 / Phosphatidylinositol 3-kinase regulatory subunit gamma / Q92569* / phosphoinositide-3-kinase regulatory subunit 3*  / complex
 ENSMUSG00000030724 Cd19 / P25918 / Mus musculus CD19 antigen (Cd19), transcript variant 2, mRNA. / P15391* / CD19 molecule*  / complex
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / complex / reaction
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex / reaction
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / complex / reaction
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / complex / reaction






 

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