ENSMUSG00000030724


Mus musculus

Features
Gene ID: ENSMUSG00000030724
  
Biological name :Cd19
  
Synonyms : Cd19 / Mus musculus CD19 antigen (Cd19), transcript variant 2, mRNA. / P25918
  
Possible biological names infered from orthology : CD19 molecule / P15391
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126408450
Gene end: 126414889
  
Corresponding Affymetrix probe sets: 10567863 (MoGene1.0st)   1450570_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032968
Ensembl peptide - ENSMUSP00000145803
NCBI entrez gene - 12478     See in Manteia.
MGI - MGI:88319
RefSeq - XM_006507283
RefSeq - NM_001357091
RefSeq - NM_009844
RefSeq - XM_006507282
RefSeq Peptide - NP_033974
RefSeq Peptide - NP_001344020
swissprot - P25918
swissprot - A0A0X1KG58
Ensembl - ENSMUSG00000030724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD19ENSG00000177455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006968 cellular defense response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IGI
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Regulation of Complement cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1Dez/Runx1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1Dez/Runx1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myctm2Fwa/Myc+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ube2ntm1Aki/Ube2ntm1Aki,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1Yai
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Runx1tm1Dez/Runx1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr9M5Btlr/?
Genetic Background: C57BL/6J-Tlr9M5Btlr

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Del(14Trim13-Rnaseh2b)6Rdf/+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnah11b2b1775Clo/Dnah11b2b1775Clo
Genetic Background: C57BL/6J-Dnah11b2b1775Clo

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Klhl6tm2Sato/Klhl6tm2Sato
Genetic Background: either: (involves: 129P2/OlaHsd * 129T2/SvEms) or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm3.1Yzo,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pbx1tm1Mlc/Pbx1tm2.1Mlc
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Prelid1tm1Hmva/Prelid1tm1Hmva,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1.1Oao/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: CrygsOpj/CrygsOpj
Genetic Background: involves: 102 * C3H/He * T STOCK

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Del(14Trim13-Rnaseh2b)6Rdf/+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mlkltm1.2Wsa/Mlkltm1.2Wsa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pdia3tm1Gjh/Pdia3tm1Gjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Ightm2Mnz/Ightm2Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Ightm1Mnz/Ightm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Palb2tm1.1Dli/Palb2tm1.1Dli,Trp53tm1Brn/Trp53+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Brca2tm1Brn/Brca2tm1Brn,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fastm1Cgn/Fastm1Cgn,Tg(Lck-cre)I57Jxm/0
Genetic Background: B6.Cg-Fastm1Cgn Tg(Lck-cre)I57Jxm

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Cgn/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Cd19tm1(cre)Cgn Fastm1Cgn Tg(Cd4-cre)1Cwi

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0004795 decreased anti-nuclear antigen antibody level "reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0004798 decreased anti-double stranded DNA antibody level "reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(Cd74*)Awai/Gt(ROSA)26Sor+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * FVB/N

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004940 abnormal B-1 B cell morphology "any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004944 abnormal B cell negative selection "any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0004976 abnormal B-1 B cell number "deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Fastm1Ach/Fastm1Ach
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Del(14Trim13-Rnaseh2b)6Rdf/+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrb+,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Klhl6tm2Sato/Klhl6tm2Sato
Genetic Background: either: (involves: 129P2/OlaHsd * 129T2/SvEms) or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Srsf3tm1Pjln/Srsf3tm1Pjln
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Tg(IghelMD4)4Ccg/0,Tg(ML5sHEL)5Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Faslpr/Fastm1Cgn,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * MRL

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mycntm2.1Nagy/Mycn+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Rev3ltm1.1Diaz/Rev3ltm1.1Diaz,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ctnnbl1tm1.1Crad/Ctnnbl1tm1.1Crad
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Rnaseh2btm1c(EUCOMM)Wtsi/Rnaseh2btm1c(EUCOMM)Wtsi,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikbkbtm2.1Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005433 deficiency of early pro-B cells "lack of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005434 deficiency of late pro-B cells "lack of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre/ERT2)Rsky/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008093 abnormal memory B cell number "anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008164 abnormal B-1a B cell morphology "any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008166 abnormal B-2 B cell morphology "any structual anomaly of a conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008172 abnormal follicular B cell morphology "any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2d+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Casp8tm1Hed/Casp8tm1Hed,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Notch2tm1Hhi/Notch2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Srftm2Nor/Srftm2Nor,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008188 abnormal transitional stage B cell morphology "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Mcm3aptm1Imku/Mcm3aptm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008193 abnormal marginal zone B cell physiology "abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Baxtm1Sjk/Baxtm2Sjk,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Irf8tm1.1Hm/Irf8tm1.1Hm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu,Tg(Vav-BCL2)1Jad/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Cgn/Ikbkbtm2.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008213 absent immature B cells "absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tcf3tm1Mbu/Tcf3tm1.2Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkgtm1.1Mpa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1.1Mgin
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008240 abnormal spleen marginal zone macrophage morphology "any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008473 abnormal spleen follicular dendritic cell network "any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2d+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ltbtm1Avt/Ltbtm1Avt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Pax5tm1Mbu/Pax5tm3Mbu
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: Not Specified

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ifnar1tm1Uka/Ifnar1tm1Uka
Genetic Background: B6.129P2-Cd19tm1(cre)Cgn Ifnar1tm1Uka

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Slc3a2tm1.1Mgin/Slc3a2tm1Yai
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Klhl6tm2Sato/Klhl6tm2Sato
Genetic Background: either: (involves: 129P2/OlaHsd * 129T2/SvEms) or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * CD-1)

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Il10tm1Roer/Il10tm1Roer
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008746 abnormal peripheral B cell anergy "any anomaly of the processes of B cell anergy that occur outside the bone marrow" [GO:0002453]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Tg(IghelMD4)4Ccg/0,Tg(ML5sHEL)5Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ube2ntm1Aki/Ube2ntm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tab2tm2.1Aki/Tab2tm2.1Aki,Tab3tm1Aki/Tab3tm1Aki,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/?,Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0009317 follicular lymphoma "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009318 splenic marginal zone lymphoma "neoplasm arising from the B cell-rich zones of the spleen" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009319 small lymphocytic lymphoma "lymphocytic leukemia where the lymphocytes are not increased in the peripheral blood, but lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Del(14Trim13-Rnaseh2b)6Rdf/+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009921 abnormal transitional stage T3 B cell morphology "any strucutral anomaly of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Adam10tm1.1Dhc/Adam10tm1.1Dhc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft
Genetic Background: B6.Cg-Cd19tm1Tft

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0010228 decreased transitional stage T3 B cell number "reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010286 increased plasmacytoma incidence "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm10(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

Allelic Composition: Gt(ROSA)26Sortm11(Lmp1)Rsky/Gt(ROSA)26Sor+,Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0010337 increased chronic lymphocytic leukemia incidence 
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Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Del(14Trim13-Rnaseh2b)6Rdf/+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Del(14Trim13-Rnaseh2b)6Rdf/+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0013940 abnormal plasmablast number "anomaly in the number of an activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative" [CL:0000980]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm2(CARD11*L225LI)Jrld/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0014050 increased B cell acute lymphoblastic leukemia incidence "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood; it is the most common type of acute lymphoblastic leukemia (ALL)" [NCIT:C8644]
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Allelic Composition: Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax5tm3Mbu/Pax5+,Tcf3tm1(PBX1)Mlc/Tcf3+,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm1.1Cmil/Ell2tm1.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ep300tm2Reck/Ep300+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000037706 Cd81 / P35762 / CD81 antigen / P60033* / CD81 molecule*  / complex
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex






 

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