ENSMUSG00000030228


Mus musculus

Features
Gene ID: ENSMUSG00000030228
  
Biological name :Pik3c2g
  
Synonyms : phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 / Pik3c2g
  
Possible biological names infered from orthology : O75747 / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G2
Gene start: 139587221
Gene end: 139969284
  
Corresponding Affymetrix probe sets: 10542477 (MoGene1.0st)   1421704_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107499
Ensembl peptide - ENSMUSP00000151281
Ensembl peptide - ENSMUSP00000141141
Ensembl peptide - ENSMUSP00000141025
Ensembl peptide - ENSMUSP00000140368
Ensembl peptide - ENSMUSP00000140123
Ensembl peptide - ENSMUSP00000032353
Ensembl peptide - ENSMUSP00000084939
NCBI entrez gene - 18705     See in Manteia.
MGI - MGI:1203730
RefSeq - NM_011084
RefSeq - NM_207683
RefSeq Peptide - NP_035214
RefSeq Peptide - NP_997566
swissprot - E9QQ35
swissprot - Q4FZD4
swissprot - D3Z6L6
swissprot - A0A1W2P6I9
swissprot - A0A087WQW4
swissprot - A0A087WQB5
Ensembl - ENSMUSG00000030228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3c2gENSDARG00000099803Danio rerio
 PIK3C2GENSGALG00000013117Gallus gallus
 O75747ENSG00000139144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pik3c2b / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSMUSG0000002644740
Pik3c2a / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSMUSG0000003066038
Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*ENSMUSG0000003246220
O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*ENSMUSG0000003993620
P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*ENSMUSG0000002766520
Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*ENSMUSG0000002057320
Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*ENSMUSG0000003362818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR001683  Phox homologous domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036871  PX domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr