ENSMUSG00000033628


Mus musculus

Features
Gene ID: ENSMUSG00000033628
  
Biological name :Pik3c3
  
Synonyms : Phosphatidylinositol 3-kinase catalytic subunit type 3 / Pik3c3 / Q6PF93
  
Possible biological names infered from orthology : Q8NEB9
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 30272747
Gene end: 30348126
  
Corresponding Affymetrix probe sets: 10454414 (MoGene1.0st)   1425580_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089601
Ensembl peptide - ENSMUSP00000128927
Ensembl peptide - ENSMUSP00000111479
Ensembl peptide - ENSMUSP00000111478
NCBI entrez gene - 225326     See in Manteia.
MGI - MGI:2445019
RefSeq - NM_181414
RefSeq Peptide - NP_852079
swissprot - E9Q824
swissprot - D3YZ98
swissprot - E9QLS6
swissprot - Q6PF93
Ensembl - ENSMUSG00000033628
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3c3ENSDARG00000054829Danio rerio
 PIK3C3ENSGALG00000035773Gallus gallus
 PIK3C3ENSG00000078142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*ENSMUSG0000003246224
Pik3c2a / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSMUSG0000003066023
Pik3c2b / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSMUSG0000002644723
O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*ENSMUSG0000003993623
P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*ENSMUSG0000002766522
Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*ENSMUSG0000002057321
Pik3c2g / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 / O75747* / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma*ENSMUSG0000003022820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR035892  C2 domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006497 protein lipidation IEA
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0016197 endosomal transport IBA
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0030242 autophagy of peroxisome IBA
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0034497 protein localization to phagophore assembly site IMP
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IMP
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0043201 response to leucine IEA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0050708 regulation of protein secretion IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000407 phagophore assembly site IBA
 cellular_componentGO:0005768 endosome IBA
 cellular_componentGO:0005770 late endosome ISS
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005777 peroxisome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
 cellular_componentGO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III IDA
 cellular_componentGO:0044754 autolysosome IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Macroautophagy
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Toll Like Receptor 9 (TLR9) Cascade
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(CAG-EGFP/Map1lc3b)53Nmz/0,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * C57BL/6NCrj * FVB/N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Astltm1Dean/Astltm1Dean
Genetic Background: involves: 129S6/SvEvTac

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd8a-cre)1Itan/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Astltm1Dean/Astltm1Dean
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd8a-cre)1Itan/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Astltm1Dean/Astltm1Dean
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd8a-cre)1Itan/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6N * C57BL/6NCrj

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Tg(CAG-EGFP/Map1lc3b)53Nmz/0,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6N * C57BL/6NCrj * FVB/N

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

Allelic Composition: Pik3c3tm1.1Flv/Pik3c3tm1.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

Allelic Composition: Pik3c3tm1Tssk/Pik3c3tm1Tssk,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: FVB/N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * DBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / reaction
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / complex
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / complex
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex / reaction
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / reaction / complex
 ENSMUSG00000035354 Uvrag / Q8K245 / UV radiation resistance associated gene / Q9P2Y5* / UV radiation resistance associated*  / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction / complex
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / complex
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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