ENSMUSG00000050697


Mus musculus

Features
Gene ID: ENSMUSG00000050697
  
Biological name :Prkaa1
  
Synonyms : Prkaa1 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q5EG47
  
Possible biological names infered from orthology : protein kinase AMP-activated catalytic subunit alpha 1 / Q13131
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 5143861
Gene end: 5181899
  
Corresponding Affymetrix probe sets: 10422707 (MoGene1.0st)   1437539_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063166
Ensembl peptide - ENSMUSP00000154562
NCBI entrez gene - 105787     See in Manteia.
MGI - MGI:2145955
RefSeq - XM_017316356
RefSeq - NM_001013367
RefSeq - NM_001355640
RefSeq - XM_006519953
RefSeq - XM_011245321
RefSeq Peptide - NP_001013385
RefSeq Peptide - NP_001342569
swissprot - Q5EG47
swissprot - Q3TUQ7
Ensembl - ENSMUSG00000050697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkaa1ENSDARG00000060596Danio rerio
 PRKAA1ENSGALG00000014832Gallus gallus
 PRKAA1ENSG00000132356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSMUSG0000002851875
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*ENSMUSG0000000977231
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*ENSMUSG0000002003231
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*ENSMUSG0000003250114
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*ENSMUSG0000002060113
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271513
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*ENSMUSG0000004260813


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR032270  AMPK, C-terminal adenylate sensor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008610 lipid biosynthetic process IDA
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0009631 cold acclimation IEA
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019395 fatty acid oxidation IMP
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0031669 cellular response to nutrient levels IDA
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IMP
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0055089 fatty acid homeostasis IEA
 biological_processGO:0060627 regulation of vesicle-mediated transport IEA
 biological_processGO:0061762 CAMKK-AMPK signaling cascade IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IGI
 biological_processGO:0071417 cellular response to organonitrogen compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1901563 response to camptothecin IMP
 biological_processGO:1903109 positive regulation of mitochondrial transcription IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:2001274 negative regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004679 AMP-activated protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035174 histone serine kinase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA
 molecular_functionGO:0050405 [acetyl-CoA carboxylase] kinase activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Prkaa1tm1Sbj/Prkaa1tm1Sbj,Prkaa2tm1Vio/Prkaa2tm1Vio,Tg(Pomc1-cre)1Gsb/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Prkaa1tm1Sbj/Prkaa1+,Prkaa2tm1Vio/Prkaa2tm1Vio
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006038 increased mitochondrial proliferation "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Srd5a1tm1Mahe/Srd5a1tm1Mahe,Srd5a2tm1Mahe/Srd5a2tm1Mahe
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003068 Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*  / reaction
 ENSMUSG00000021096 Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*  / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / reaction / complex
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / complex
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / complex / reaction
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / reaction
 ENSMUSG00000002496 Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*  / reaction
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction
 ENSMUSG00000038332 Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*  / reaction / complex
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / complex
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / reaction
 ENSMUSG00000026812 Tsc1 / Q9EP53 / Hamartin / Q92574* / TSC complex subunit 1*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / complex / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / complex
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction
 ENSMUSG00000028893 Sesn2 / P58043 / Sestrin-2 / P58004*  / complex / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / reaction






 

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