ENSMUSG00000032501


Mus musculus

Features
Gene ID: ENSMUSG00000032501
  
Biological name :Trib1
  
Synonyms : Q8K4K4 / Trib1 / Tribbles homolog 1
  
Possible biological names infered from orthology : Q96RU8 / tribbles pseudokinase 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 59648350
Gene end: 59657099
  
Corresponding Affymetrix probe sets: 10424370 (MoGene1.0st)   1424880_at (Mouse Genome 430 2.0 Array)   1424881_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068834
Ensembl peptide - ENSMUSP00000112828
NCBI entrez gene - 211770     See in Manteia.
MGI - MGI:2443397
RefSeq - NM_144549
RefSeq Peptide - NP_653132
swissprot - Q8K4K4
Ensembl - ENSMUSG00000032501
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trib1ENSDARG00000110963Danio rerio
 TRIB1ENSGALG00000036456Gallus gallus
 TRIB1ENSG00000173334Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*ENSMUSG0000002060153
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271544
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*ENSMUSG0000002003226
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*ENSMUSG0000000977225
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*ENSMUSG0000004260823
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*ENSMUSG0000005069721
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSMUSG0000002851821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40
 IPR024105  Tribbles homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0007254 JNK cascade ISO
 biological_processGO:0014912 negative regulation of smooth muscle cell migration ISO
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0043405 regulation of MAP kinase activity ISO
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045645 positive regulation of eosinophil differentiation IMP
 biological_processGO:0045651 positive regulation of macrophage differentiation IMP
 biological_processGO:0045659 negative regulation of neutrophil differentiation IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISO
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IC
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0055106 ubiquitin-protein transferase regulator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
Show

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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