ENSMUSG00000020601


Mus musculus

Features
Gene ID: ENSMUSG00000020601
  
Biological name :Trib2
  
Synonyms : Q8K4K3 / Trib2 / Tribbles homolog 2
  
Possible biological names infered from orthology : Q92519 / tribbles pseudokinase 2
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 15791727
Gene end: 15816922
  
Corresponding Affymetrix probe sets: 10399470 (MoGene1.0st)   1426640_s_at (Mouse Genome 430 2.0 Array)   1426641_at (Mouse Genome 430 2.0 Array)   1459852_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152535
Ensembl peptide - ENSMUSP00000152685
Ensembl peptide - ENSMUSP00000020922
NCBI entrez gene - 217410     See in Manteia.
MGI - MGI:2145021
RefSeq - XM_006515054
RefSeq - XM_006515055
RefSeq - NM_144551
RefSeq Peptide - NP_653134
swissprot - Q8K4K3
swissprot - A0A1Y7VK24
swissprot - A0A1Y7VJR1
Ensembl - ENSMUSG00000020601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trib2ENSDARG00000068179Danio rerio
 TRIB2ENSGALG00000016457Gallus gallus
 TRIB2ENSG00000071575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*ENSMUSG0000003250158
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271549
Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*ENSMUSG0000002003227
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*ENSMUSG0000000977226
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*ENSMUSG0000004260823
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSMUSG0000002851823
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*ENSMUSG0000005069722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043405 regulation of MAP kinase activity IBA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IC
 biological_processGO:0045081 negative regulation of interleukin-10 biosynthetic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IC
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0055106 ubiquitin-protein transferase regulator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: BALB/c

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Qpcttm1.2Tbay/Qpcttm1.2Tbay,Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Qpctlm1Ingm/Qpctlm1Ingm,Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Genetic Background: involves: C3HeB/FeJ

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0010014 hippocampus pyramidal cell degeneration "a retrogressive impairment or destruction of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+,Tg(Thy1-APP*)2.2Ingm/0
Genetic Background: involves: C57BL/6 * DBA/1

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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