ENSG00000071575


Homo sapiens

Features
Gene ID: ENSG00000071575
  
Biological name :TRIB2
  
Synonyms : Q92519 / TRIB2 / tribbles pseudokinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p24.3
Gene start: 12716889
Gene end: 12742734
  
Corresponding Affymetrix probe sets: 202478_at (Human Genome U133 Plus 2.0 Array)   202479_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000155926
Ensembl peptide - ENSP00000384260
Ensembl peptide - ENSP00000370874
NCBI entrez gene - 28951     See in Manteia.
OMIM - 609462
RefSeq - NM_021643
RefSeq Peptide - NP_067675
swissprot - B5MCX4
swissprot - F8WA18
swissprot - Q92519
Ensembl - ENSG00000071575
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trib2ENSDARG00000068179Danio rerio
 TRIB2ENSGALG00000016457Gallus gallus
 Trib2ENSMUSG00000020601Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIB1 / Q96RU8 / tribbles pseudokinase 1ENSG0000017333459
TRIB3 / Q96RU7 / tribbles pseudokinase 3ENSG0000010125545
NUAK1 / O60285 / NUAK family kinase 1ENSG0000007459026
NUAK2 / Q9H093 / NUAK family kinase 2ENSG0000016354526
STK40 / Q8N2I9 / serine/threonine kinase 40ENSG0000019618223
P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2ENSG0000016240923
PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1ENSG0000013235622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity NAS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043405 regulation of MAP kinase activity IBA
 biological_processGO:0045081 negative regulation of interleukin-10 biosynthetic process IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0055106 ubiquitin-protein transferase regulator activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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