ENSG00000101255


Homo sapiens

Features
Gene ID: ENSG00000101255
  
Biological name :TRIB3
  
Synonyms : Q96RU7 / TRIB3 / tribbles pseudokinase 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p13
Gene start: 362835
Gene end: 397559
  
Corresponding Affymetrix probe sets: 1555788_a_at (Human Genome U133 Plus 2.0 Array)   218145_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000415416
Ensembl peptide - ENSP00000478194
Ensembl peptide - ENSP00000217233
Ensembl peptide - ENSP00000391873
NCBI entrez gene - 57761     See in Manteia.
OMIM - 607898
RefSeq - XM_017027989
RefSeq - NM_001301188
RefSeq - NM_001301190
RefSeq - NM_001301193
RefSeq - NM_001301196
RefSeq - NM_001301201
RefSeq - NM_021158
RefSeq Peptide - NP_001288122
RefSeq Peptide - NP_001288125
RefSeq Peptide - NP_001288130
RefSeq Peptide - NP_066981
RefSeq Peptide - NP_001288117
RefSeq Peptide - NP_001288119
swissprot - J3KR25
swissprot - A0A087WTX3
swissprot - B0QYQ2
swissprot - Q96RU7
Ensembl - ENSG00000101255
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trib3ENSDARG00000016200Danio rerio
 Trib3ENSMUSG00000032715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIB1 / Q96RU8 / tribbles pseudokinase 1ENSG0000017333442
TRIB2 / Q92519 / tribbles pseudokinase 2ENSG0000007157541
STK40 / Q8N2I9 / serine/threonine kinase 40ENSG0000019618225
NUAK1 / O60285 / NUAK family kinase 1ENSG0000007459024
NUAK2 / Q9H093 / NUAK family kinase 2ENSG0000016354523
P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2ENSG0000016240920
PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1ENSG0000013235619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR024104  Pseudokinase tribbles family/serine-threonine-protein kinase 40
 IPR024106  Pseudokinase tribbles, TRB3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010827 regulation of glucose transmembrane transport IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0043405 regulation of MAP kinase activity IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0055106 ubiquitin-protein transferase regulator activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Activation of AKT2
PPARA activates gene expression
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / complex / reaction
 ENSG00000105221 AKT2 / P31751 / AKT serine/threonine kinase 2  / complex






 

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