ENSG00000074590


Homo sapiens

Features
Gene ID: ENSG00000074590
  
Biological name :NUAK1
  
Synonyms : NUAK1 / NUAK family kinase 1 / O60285
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q23.3
Gene start: 106063340
Gene end: 106140033
  
Corresponding Affymetrix probe sets: 204589_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448288
Ensembl peptide - ENSP00000449990
Ensembl peptide - ENSP00000261402
Ensembl peptide - ENSP00000446873
NCBI entrez gene - 9891     See in Manteia.
OMIM - 608130
RefSeq - NM_014840
RefSeq Peptide - NP_055655
swissprot - F8VXF0
swissprot - A0A024RBL3
swissprot - O60285
swissprot - F8VZ96
swissprot - F8VSH4
Ensembl - ENSG00000074590
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nuak1aENSDARG00000020086Danio rerio
 nuak1bENSDARG00000028676Danio rerio
 NUAK1ENSGALG00000012662Gallus gallus
 Nuak1ENSMUSG00000020032Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NUAK2 / Q9H093 / NUAK family kinase 2ENSG0000016354555
PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1ENSG0000013235627
P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2ENSG0000016240926
TRIB1 / Q96RU8 / tribbles pseudokinase 1ENSG0000017333414
TRIB2 / Q92519 / tribbles pseudokinase 2ENSG0000007157514
TRIB3 / Q96RU7 / tribbles pseudokinase 3ENSG0000010125514
STK40 / Q8N2I9 / serine/threonine kinase 40ENSG0000019618212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0035507 regulation of myosin-light-chain-phosphatase activity IDA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:2000772 regulation of cellular senescence IDA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000118046 STK11 / Q15831 / serine/threonine kinase 11  / complex / reaction






 

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