ENSMUSG00000020032


Mus musculus

Features
Gene ID: ENSMUSG00000020032
  
Biological name :Nuak1
  
Synonyms : Nuak1 / NUAK family SNF1-like kinase 1 / Q641K5
  
Possible biological names infered from orthology : NUAK family kinase 1 / O60285
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 84370905
Gene end: 84440597
  
Corresponding Affymetrix probe sets: 10371379 (MoGene1.0st)   1438684_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020220
Ensembl peptide - ENSMUSP00000122927
NCBI entrez gene - 77976     See in Manteia.
MGI - MGI:1925226
RefSeq - NM_001004363
RefSeq - XM_011243603
RefSeq Peptide - NP_001004363
swissprot - F6XZX4
swissprot - Q641K5
Ensembl - ENSMUSG00000020032
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nuak1aENSDARG00000020086Danio rerio
 nuak1bENSDARG00000028676Danio rerio
 NUAK1ENSGALG00000012662Gallus gallus
 NUAK1ENSG00000074590Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nuak2 / Q8BZN4 / NUAK family SNF1-like kinase 2 / Q9H093* / NUAK family kinase 2*ENSMUSG0000000977254
Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*ENSMUSG0000005069726
Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*ENSMUSG0000002851825
Trib2 / Q8K4K3 / Tribbles homolog 2 / Q92519* / tribbles pseudokinase 2*ENSMUSG0000002060114
Trib1 / Q8K4K4 / Tribbles homolog 1 / Q96RU8* / tribbles pseudokinase 1*ENSMUSG0000003250114
Trib3 / Q8K4K2 / Tribbles homolog 3 / Q96RU7* / tribbles pseudokinase 3*ENSMUSG0000003271514
Stk40 / Q7TNL3 / Serine/threonine-protein kinase 40 / Q8N2I9* / serine/threonine kinase 40*ENSMUSG0000004260812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0035507 regulation of myosin-light-chain-phosphatase activity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:2000772 regulation of cellular senescence IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm1Brn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Itgb1tm1Ref/Itgb1tm1Ref,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
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Allelic Composition: Nuak1tm1Sia/Nuak1tm1Sia,Nuak2tm1Sia/Nuak2tm1Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000003068 Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*  / complex / reaction






 

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