ENSMUSG00000003068


Mus musculus

Features
Gene ID: ENSMUSG00000003068
  
Biological name :Stk11
  
Synonyms : Q9WTK7 / Serine/threonine-protein kinase STK11 / Stk11
  
Possible biological names infered from orthology : Q15831 / serine/threonine kinase 11
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80115803
Gene end: 80130682
  
Corresponding Affymetrix probe sets: 10364683 (MoGene1.0st)   1418644_a_at (Mouse Genome 430 2.0 Array)   1448062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003152
Ensembl peptide - ENSMUSP00000114195
Ensembl peptide - ENSMUSP00000150488
Ensembl peptide - ENSMUSP00000118853
Ensembl peptide - ENSMUSP00000101009
Ensembl peptide - ENSMUSP00000101010
NCBI entrez gene - 20869     See in Manteia.
MGI - MGI:1341870
RefSeq - NM_011492
RefSeq - XM_006513442
RefSeq - XM_006513439
RefSeq - NM_001301853
RefSeq - NM_001301854
RefSeq Peptide - NP_001288782
RefSeq Peptide - NP_001288783
RefSeq Peptide - NP_035622
swissprot - F6WNS2
swissprot - Q9WTK7
swissprot - E9Q811
swissprot - D6RGT4
Ensembl - ENSMUSG00000003068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk11ENSDARG00000046074Danio rerio
 STK11ENSGALG00000040008Gallus gallus
 STK11ENSG00000118046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camkk2 / Q8C078 / Calcium/calmodulin-dependent protein kinase kinase 2 / Q96RR4*ENSMUSG0000002947128
Camkk1 / Q8VBY2 / Calcium/calmodulin-dependent protein kinase kinase 1 / Q8N5S9*ENSMUSG0000002078527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IDA
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0032147 activation of protein kinase activity ISO
 biological_processGO:0036399 TCR signalosome assembly IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043276 anoikis ISO
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050772 positive regulation of axonogenesis IGI
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051055 negative regulation of lipid biosynthetic process IMP
 biological_processGO:0051645 Golgi localization IMP
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0071493 cellular response to UV-B ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISS
 biological_processGO:0097484 dendrite extension IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus IMP
 biological_processGO:1904262 negative regulation of TORC1 signaling ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0036398 TCR signalosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0002039 p53 binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030275 LRR domain binding IPI
 molecular_functionGO:0030295 protein kinase activator activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Energy dependent regulation of mTOR by LKB1-AMPK
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Tcrbtm1Mom/Tcrbtm1Mom,Tcrdtm1Mom/Tcrdtm1Mom,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

 MP:0001272 increased metastatic potential 
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Stk11tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Maeltm1Bort/Maeltm1Bort
Genetic Background: B6.129S4-Maeltm1Bort

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

 MP:0001711 abnormal placenta 
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1Mmt/Stk11+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

Allelic Composition: Stk11tm1Mmt/Stk11+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Maeltm1Bort/Maeltm1Bort
Genetic Background: B6.129S4-Maeltm1Bort

Allelic Composition: Stk11tm2.1Arte/Stk11tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003299 gastric polyps "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

Allelic Composition: Stk11tm1.1Mlfr/Stk11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1Mmt/Stk11+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Stk11tm1Mmt/Stk11+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0003334 pancreatic fibrosis "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pdx1tm1Egs/Pdx1+,Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic Background: involves: 129S1/Sv * C57BL/6N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S6/SvEvTac

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004868 endometrial carcinoma "malignant neoplasm arising from the endometrial tissue" [RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lep+
Genetic Background: involves: C57BL/6J

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004902 abnormal uterus size "anomaly in the size of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Chuktm2Yhu/Chuktm2Yhu,Tg(Lor-CHUK)8Yhu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S6/SvEvTac

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1.1Arte/Stk11tm1.1Arte
Genetic Background: involves: C57BL/6J

 MP:0006038 increased mitochondrial proliferation "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighatm1(Myc)Janz/Igha+,Tg(Tnfsf13b)1Fma/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0006342 absent first branchial arch "missing the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lep+
Genetic Background: involves: C57BL/6J

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ptgs2tm1Jed/Ptgs2tm1Jed,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Ptgs2tm1Jed/Ptgs2+,Stk11tm1Tpm/Stk11+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0008012 duodenal polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1Tpm/Stk11+
Genetic Background: Not Specified

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008717 lung squamous cell carcinoma "a lung carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008718 lung large cell carcinoma "a bronchogenic tumor of undifferentiated (anaplastic) cells of large size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.1Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Stk11tm1.1Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009181 decreased pancreatic delta cell number "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Stk11tm1.1Sjm/Stk11tm1.1Sjm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0009550 urinary bladder carcinoma "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0009552 urinary bladder obstruction "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Sprr2f-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0009656 delayed chorioallantoic fusion "late onset of the initiation and/or completion of the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp2tm1Her/Lrp2tm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Stk11tm1.1Sjm/Stk11tm1.1Sjm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1Mmt/Stk11+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Stk11tm1Mmt/Stk11+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0010322 increased cutaneous melanoma incidence "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Stk11tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos

 MP:0010352 gastrointestinal tract polyps "abnormal tissue masses that protrude into the lumen of the gastrointestinal tract and are tethered to the wall of the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Stk11tm1.1Rdp/Stk11tm1.1Rdp,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Stk11tm1.2Rdp/Stk11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

 MP:0010906 abnormal lung bud morphology "any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Akt3tm1Hem/Akt3tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stk11tm1.2Rdp/Stk11tm1.2Rdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Allelic Composition: Stk11tm1Mmt/Stk11tm1Mmt
Genetic Background: involves: 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

Allelic Composition: Stk11tm1Tpm/Stk11tm1Tpm
Genetic Background: Not Specified

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Trp53bp1tm1Jc/Trp53bp1tm1Jc,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Stk11tm1Tpm/Stk11tm1Tpm
Genetic Background: Not Specified

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: either: B6SJL.129-Chrdtm1Emdr or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J)

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011766 abnormal urinary bladder mucosa morphology "any structural anomaly of the mucous membrane lining the urinary bladder" [MGI:anna]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0011874 enlarged urinary bladder "increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [MGI:Colin_McKerlie]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0013220 increased pancreas apoptosis "increase in the number of cells of the pancreas undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0013267 first pharyngeal arch hypoplasia "underdevelopment or reduced size of the first pharyngeal arch, usually due to reduced cell number" [MGI:anna]
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Allelic Composition: Stk11tm1Tpm/Stk11tm1Tpm
Genetic Background: Not Specified

Allelic Composition: Stk11tm2.1Tpm/Stk11tm2.1Tpm
Genetic Background: involves: BALB/c * C57BL/6

 MP:0013328 visceromegaly "abnormal enlargement of the viscera, esp. internal organs in the abdomen, including liver, spleen, stomach, kidneys, and pancreas" [MGI:Anna]
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Allelic Composition: Stk11tm1.1Mlfr/Stk11+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036707 Cab39 / Q06138 / Mus musculus calcium binding protein 39 (Cab39), transcript variant 3, mRNA. / Q9Y376* / calcium binding protein 39*  / complex / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000021981 Cab39l / Q9DB16 / Calcium-binding protein 39-like / Q9H9S4*  / reaction / complex
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000069631 Q3UUJ4 / Strada / STE20-related kinase adapter protein alpha / Q7RTN6* / STE20-related kinase adaptor alpha*  / complex / reaction
 ENSMUSG00000020032 Nuak1 / Q641K5 / NUAK family SNF1-like kinase 1 / O60285* / NUAK family kinase 1*  / complex / reaction
 ENSMUSG00000026027 Q8K4T3 / Stradb / STE20-related kinase adapter protein beta / Q9C0K7* / STE20-related kinase adaptor beta*  / reaction / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
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