ENSMUSG00000020785


Mus musculus

Features
Gene ID: ENSMUSG00000020785
  
Biological name :Camkk1
  
Synonyms : Calcium/calmodulin-dependent protein kinase kinase 1 / Camkk1 / Q8VBY2
  
Possible biological names infered from orthology : Q8N5S9
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B4
Gene start: 73019008
Gene end: 73042073
  
Corresponding Affymetrix probe sets: 10378253 (MoGene1.0st)   1418954_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090613
Ensembl peptide - ENSMUSP00000123441
NCBI entrez gene - 55984     See in Manteia.
MGI - MGI:1891766
RefSeq - XM_006533761
RefSeq - NM_018883
RefSeq - XM_006533760
RefSeq Peptide - NP_061371
swissprot - Q8VBY2
swissprot - B1AUD3
Ensembl - ENSMUSG00000020785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camkk1aENSDARG00000035452Danio rerio
 camkk1bENSDARG00000015134Danio rerio
 CAMKK1ENSGALG00000001617Gallus gallus
 CAMKK1ENSG00000004660Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camkk2 / Q8C078 / Calcium/calmodulin-dependent protein kinase kinase 2 / Q96RR4*ENSMUSG0000002947157
Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*ENSMUSG0000000306823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045860 positive regulation of protein kinase activity IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity ISS
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
CREB phosphorylation through the activation of CaMKK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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