ENSMUSG00000029471


Mus musculus

Features
Gene ID: ENSMUSG00000029471
  
Biological name :Camkk2
  
Synonyms : Calcium/calmodulin-dependent protein kinase kinase 2 / Camkk2 / Q8C078
  
Possible biological names infered from orthology : Q96RR4
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 122731170
Gene end: 122779409
  
Corresponding Affymetrix probe sets: 10533529 (MoGene1.0st)   1424474_a_at (Mouse Genome 430 2.0 Array)   1424475_at (Mouse Genome 430 2.0 Array)   1424476_at (Mouse Genome 430 2.0 Array)   1455401_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142751
Ensembl peptide - ENSMUSP00000142812
Ensembl peptide - ENSMUSP00000143732
Ensembl peptide - ENSMUSP00000143730
Ensembl peptide - ENSMUSP00000143162
Ensembl peptide - ENSMUSP00000142896
Ensembl peptide - ENSMUSP00000107297
Ensembl peptide - ENSMUSP00000142717
NCBI entrez gene - 207565     See in Manteia.
MGI - MGI:2444812
RefSeq - XM_006530230
RefSeq - XM_006530232
RefSeq - XM_006530233
RefSeq - XM_006530234
RefSeq - XM_006530235
RefSeq - XM_006530236
RefSeq - XM_017320763
RefSeq - NM_145358
RefSeq - XM_006530231
RefSeq - NM_001199676
RefSeq Peptide - NP_001186605
RefSeq Peptide - NP_663333
swissprot - Q3TV45
swissprot - A0A0G2JFG5
swissprot - A0A0G2JET2
swissprot - A0A0G2JEF4
swissprot - A0A0G2JEC5
swissprot - A0A0G2JGX0
swissprot - Q8C078
Ensembl - ENSMUSG00000029471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-62l21.1ENSDARG00000078645Danio rerio
 CAMKK2ENSGALG00000040131Gallus gallus
 CAMKK2ENSG00000110931Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camkk1 / Q8VBY2 / Calcium/calmodulin-dependent protein kinase kinase 1 / Q8N5S9*ENSMUSG0000002078549
Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*ENSMUSG0000000306821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045860 positive regulation of protein kinase activity IBA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0061762 CAMKK-AMPK signaling cascade ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lamb2tm1Jrs/Lamb2tm1Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Adam10tm1Zhu/Adam10tm1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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